The M gamma chain of human fetal hemoglobin.

T. H. Huisman, Ferdane Kutlar, Abdullah Kutlar, J. B. Wilson, H. F. Harris

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A new gamma chain of human fetal hemoglobin, the M gamma chain, has been detected by high performance liquid chromatography (HPLC). It is characterized by a Leu----Met replacement at position gamma 141; no other structural variations have been found. The M gamma chain has been observed in red cell lysates of subjects with a heterozygosity for one of many types of hereditary persistence of fetal hemoglobin (HPFH), in sickle cell anemia, and in a few cord blood samples. At present, the genetic cause of this newly discovered heterogeneity is not known; an infidelity in translation or the existence of an unrecognized gamma globin gene should be considered.

Original languageEnglish (US)
Pages (from-to)507-517
Number of pages11
JournalProgress in Clinical and Biological Research
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • General Medicine


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