The monoclonal antibody A2B5 is specific to ganglioside GQ1c

Noriyuki Kasai; Robert K. Yu

doi:10.1016/0006-8993(83)90918-6

The monoclonal antibody A2B5 is specific to ganglioside G_Q1c

Noriyuki Kasai, Robert K. Yu

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

The neural specific monoclonal antibody A2B5 was found to interact with G_Q1c but not with G_Q1b, nor did it interact with other glycolipids such as G_M1, G_D1a, G_D1b, G_T1a, G_T1b and G_A1. Since G_Q1c is enriched in embryonic chicken brains but not in adult chicken brains, this antibody should be useful as a tool in assessing the role of G_Q1c in neuronal maturation.

Original language	English (US)
Pages (from-to)	155-158
Number of pages	4
Journal	Brain Research
Volume	277
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(83)90918-6
State	Published - Oct 24 1983
Externally published	Yes

Keywords

gangliosides
monoclonal antibody A2B5
neuronal maturation
tetrasialoganglosides

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(83)90918-6

Cite this

@article{f32122473d044e03bb38ed66193983a7,

title = "The monoclonal antibody A2B5 is specific to ganglioside GQ1c",

abstract = "The neural specific monoclonal antibody A2B5 was found to interact with GQ1c but not with GQ1b, nor did it interact with other glycolipids such as GM1, GD1a, GD1b, GT1a, GT1b and GA1. Since GQ1c is enriched in embryonic chicken brains but not in adult chicken brains, this antibody should be useful as a tool in assessing the role of GQ1c in neuronal maturation.",

keywords = "gangliosides, monoclonal antibody A2B5, neuronal maturation, tetrasialoganglosides",

author = "Noriyuki Kasai and Yu, {Robert K.}",

note = "Funding Information: This work was supported by USPHS Grant NS-11853, and, in part, by NMSS Grant RG 1289-B-3. We thank Drs. S. Ando and K. Kato for helpful discussions.",

year = "1983",

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T1 - The monoclonal antibody A2B5 is specific to ganglioside GQ1c

AU - Kasai, Noriyuki

AU - Yu, Robert K.

N1 - Funding Information: This work was supported by USPHS Grant NS-11853, and, in part, by NMSS Grant RG 1289-B-3. We thank Drs. S. Ando and K. Kato for helpful discussions.

PY - 1983/10/24

Y1 - 1983/10/24

N2 - The neural specific monoclonal antibody A2B5 was found to interact with GQ1c but not with GQ1b, nor did it interact with other glycolipids such as GM1, GD1a, GD1b, GT1a, GT1b and GA1. Since GQ1c is enriched in embryonic chicken brains but not in adult chicken brains, this antibody should be useful as a tool in assessing the role of GQ1c in neuronal maturation.

AB - The neural specific monoclonal antibody A2B5 was found to interact with GQ1c but not with GQ1b, nor did it interact with other glycolipids such as GM1, GD1a, GD1b, GT1a, GT1b and GA1. Since GQ1c is enriched in embryonic chicken brains but not in adult chicken brains, this antibody should be useful as a tool in assessing the role of GQ1c in neuronal maturation.

KW - gangliosides

KW - monoclonal antibody A2B5

KW - neuronal maturation

KW - tetrasialoganglosides

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