TY - JOUR
T1 - The repertoire of T cells shaped by a single MHC/peptide ligand
AU - Ignatowicz, Leszek
AU - Kappler, John
AU - Marrack, Philippa
N1 - Funding Information:
The authors are very grateful to Drs. Donal Murphy and Charles A. Janeway, Jr., for the B cell hybridomas Y3P and YAe; Drs. Diane Mathis, Christophe Benoist, Ronald Germain, and Jerry Bill for class II promoter and structural genes; and Drs. Elizabeth Bikoff and Ronald Germain for the invariant chain knockout mice. The authors would like to thank Dr. David Parker for many helpful discussions; Drs. Mark Scherer and Tony Vella for their comments on the manuscript; and Helena Gognat, Christopher Brown, and Ella Kushnir for breeding the mice used in these experiments. This work was supported in part by United States Public Health Service grants AI-18785, AI-17134, and AI-22295.
PY - 1996/2/23
Y1 - 1996/2/23
N2 - Although the thymus produces many immature thymocytes, few of these cells mature. Positive selection has been thought to limit thymocyte development. In thymuses expressing a single MHC/peptide combination, however, surprisingly large numbers of thymocytes are selected to mature. Many of these react with the selecting MHC, bound to other self-peptides. Therefore, the number of thymocytes that mature is limited by the fact that positively selected cells die because they react too well with MHC bound to self- peptides that are not identical to those involved in positive selection. T cells that mature in thymuses expressing a single MHC/peptide ligand react frequently with foreign MHC, suggesting that the repertoire of αβ receptors may be more biased toward reaction with MHC than was previously thought.
AB - Although the thymus produces many immature thymocytes, few of these cells mature. Positive selection has been thought to limit thymocyte development. In thymuses expressing a single MHC/peptide combination, however, surprisingly large numbers of thymocytes are selected to mature. Many of these react with the selecting MHC, bound to other self-peptides. Therefore, the number of thymocytes that mature is limited by the fact that positively selected cells die because they react too well with MHC bound to self- peptides that are not identical to those involved in positive selection. T cells that mature in thymuses expressing a single MHC/peptide ligand react frequently with foreign MHC, suggesting that the repertoire of αβ receptors may be more biased toward reaction with MHC than was previously thought.
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U2 - 10.1016/S0092-8674(00)81028-4
DO - 10.1016/S0092-8674(00)81028-4
M3 - Article
C2 - 8598039
AN - SCOPUS:0030058657
SN - 0092-8674
VL - 84
SP - 521
EP - 529
JO - Cell
JF - Cell
IS - 4
ER -