The results of epididymal ablation by sclerosing agents in the nonhuman primate

R. W. Lewis; R. R. Garcia

doi:10.1016/S0015-0282(16)47729-0

The results of epididymal ablation by sclerosing agents in the nonhuman primate

R. W. Lewis, R. R. Garcia

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The purpose of this 6-month study was to see whether azoospermia could be produced by injection of sclerosing agents into the cauda epididymides. Three groups of monkeys had bilateral cauda epididymides injections with (1) 0.5 ml of 4% formalin in glycerol, (2) 0.5 ml of methylcyanoacrylate (MCA), or (3) 100 mg of quinacrine hydrochloride in 2 ml of saline. Failure rates were very high in the formalin and quinacrine groups (60% and 75%, respectively). Three animals given quinacrine died unexpectedly. In the MCA group the failure rate was 40%. Local tissue reaction to the sclerosing agent was minimal with MCA, compared with the other two agents.

Original language	English (US)
Pages (from-to)	465-469
Number of pages	5
Journal	Fertility and sterility
Volume	41
Issue number	3
DOIs	https://doi.org/10.1016/S0015-0282(16)47729-0
State	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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@article{c6273fd17820494aa0a563c3fd02ae72,

title = "The results of epididymal ablation by sclerosing agents in the nonhuman primate",

abstract = "The purpose of this 6-month study was to see whether azoospermia could be produced by injection of sclerosing agents into the cauda epididymides. Three groups of monkeys had bilateral cauda epididymides injections with (1) 0.5 ml of 4% formalin in glycerol, (2) 0.5 ml of methylcyanoacrylate (MCA), or (3) 100 mg of quinacrine hydrochloride in 2 ml of saline. Failure rates were very high in the formalin and quinacrine groups (60% and 75%, respectively). Three animals given quinacrine died unexpectedly. In the MCA group the failure rate was 40%. Local tissue reaction to the sclerosing agent was minimal with MCA, compared with the other two agents.",

author = "Lewis, {R. W.} and Garcia, {R. R.}",

note = "Funding Information: Received May 2, 1983; revised and.accepted November 16, 1983. *The research data presented in this publication have been wholly supported by the Program for Allied Research on Fertility Regulation, Northwestern University, under a cooperative agreement with the Agency for International Development (DPE-0546-A-00-1003-00) and RR 00164. tReprint requests: Ronald W. Lewis, M.D., Department of Urology, Tulane University, Delta Regional Primate Research Center, Covington, Louisiana 70433.",

year = "1984",

doi = "10.1016/S0015-0282(16)47729-0",

language = "English (US)",

volume = "41",

pages = "465--469",

journal = "Fertility and sterility",

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publisher = "Elsevier Inc.",

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TY - JOUR

T1 - The results of epididymal ablation by sclerosing agents in the nonhuman primate

AU - Lewis, R. W.

AU - Garcia, R. R.

N1 - Funding Information: Received May 2, 1983; revised and.accepted November 16, 1983. *The research data presented in this publication have been wholly supported by the Program for Allied Research on Fertility Regulation, Northwestern University, under a cooperative agreement with the Agency for International Development (DPE-0546-A-00-1003-00) and RR 00164. tReprint requests: Ronald W. Lewis, M.D., Department of Urology, Tulane University, Delta Regional Primate Research Center, Covington, Louisiana 70433.

PY - 1984

Y1 - 1984

N2 - The purpose of this 6-month study was to see whether azoospermia could be produced by injection of sclerosing agents into the cauda epididymides. Three groups of monkeys had bilateral cauda epididymides injections with (1) 0.5 ml of 4% formalin in glycerol, (2) 0.5 ml of methylcyanoacrylate (MCA), or (3) 100 mg of quinacrine hydrochloride in 2 ml of saline. Failure rates were very high in the formalin and quinacrine groups (60% and 75%, respectively). Three animals given quinacrine died unexpectedly. In the MCA group the failure rate was 40%. Local tissue reaction to the sclerosing agent was minimal with MCA, compared with the other two agents.

AB - The purpose of this 6-month study was to see whether azoospermia could be produced by injection of sclerosing agents into the cauda epididymides. Three groups of monkeys had bilateral cauda epididymides injections with (1) 0.5 ml of 4% formalin in glycerol, (2) 0.5 ml of methylcyanoacrylate (MCA), or (3) 100 mg of quinacrine hydrochloride in 2 ml of saline. Failure rates were very high in the formalin and quinacrine groups (60% and 75%, respectively). Three animals given quinacrine died unexpectedly. In the MCA group the failure rate was 40%. Local tissue reaction to the sclerosing agent was minimal with MCA, compared with the other two agents.

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DO - 10.1016/S0015-0282(16)47729-0

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EP - 469

JO - Fertility and sterility

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IS - 3

ER -

The results of epididymal ablation by sclerosing agents in the nonhuman primate

Abstract

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