TY - JOUR
T1 - The Role of Adverse Childhood Experiences in Cardiovascular Disease Risk
T2 - a Review with Emphasis on Plausible Mechanisms
AU - Su, Shaoyong
AU - Jimenez, Marcia P.
AU - Roberts, Cole T.F.
AU - Loucks, Eric B.
N1 - Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2015/10/21
Y1 - 2015/10/21
N2 - Childhood adversity, characterized by abuse, neglect, and household dysfunction, is a problem that exerts a significant impact on individuals, families, and society. Growing evidence suggests that adverse childhood experiences (ACEs) are associated with health decline in adulthood, including cardiovascular disease (CVD). In the current review, we first provide an overview of the association between ACEs and CVD risk, with updates on the latest epidemiological evidence. Second, we briefly review plausible pathways by which ACEs could influence CVD risk, including traditional risk factors and novel mechanisms. Finally, we highlight the potential implications of ACEs in clinical and public health. Information gleaned from this review should help physicians and researchers in better understanding potential long-term consequences of ACEs and considering adapting current strategies in treatment or intervention for patients with ACEs.
AB - Childhood adversity, characterized by abuse, neglect, and household dysfunction, is a problem that exerts a significant impact on individuals, families, and society. Growing evidence suggests that adverse childhood experiences (ACEs) are associated with health decline in adulthood, including cardiovascular disease (CVD). In the current review, we first provide an overview of the association between ACEs and CVD risk, with updates on the latest epidemiological evidence. Second, we briefly review plausible pathways by which ACEs could influence CVD risk, including traditional risk factors and novel mechanisms. Finally, we highlight the potential implications of ACEs in clinical and public health. Information gleaned from this review should help physicians and researchers in better understanding potential long-term consequences of ACEs and considering adapting current strategies in treatment or intervention for patients with ACEs.
KW - Adverse childhood experiences
KW - Cardiovascular disease
KW - Childhood maltreatment
KW - Depression
KW - Intervention
KW - Risky behaviors
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U2 - 10.1007/s11886-015-0645-1
DO - 10.1007/s11886-015-0645-1
M3 - Review article
C2 - 26289252
AN - SCOPUS:84939611621
SN - 1523-3782
VL - 17
JO - Current Cardiology Reports
JF - Current Cardiology Reports
IS - 10
M1 - 88
ER -
