TY - JOUR
T1 - The role of antibodies and B cells in the pathogenesis of lupus nephritis
AU - Shlomchik, Mark J.
AU - Madaio, Michael P.
PY - 2003/5/1
Y1 - 2003/5/1
N2 - Nephritis occurs commonly in lupus patients, and many immunological and nonimmunological factors contribute to disease expression. It is generally appreciated that glomerular immune deposit formation is an early and initiating event, although the mechanisms leading to the deposition of nephritogenic antibodies continue to be debated. Furthermore, it has recently become evident that autoantibodies expressed on B cells also play an important role in pathogenesis. This review focuses on the properties of nephritogenic autoantibodies, their mechanisms of immune deposit formation, and the contribution of B cells expressing autoantibodies to lupus nephritis.
AB - Nephritis occurs commonly in lupus patients, and many immunological and nonimmunological factors contribute to disease expression. It is generally appreciated that glomerular immune deposit formation is an early and initiating event, although the mechanisms leading to the deposition of nephritogenic antibodies continue to be debated. Furthermore, it has recently become evident that autoantibodies expressed on B cells also play an important role in pathogenesis. This review focuses on the properties of nephritogenic autoantibodies, their mechanisms of immune deposit formation, and the contribution of B cells expressing autoantibodies to lupus nephritis.
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U2 - 10.1007/s00281-003-0119-1
DO - 10.1007/s00281-003-0119-1
M3 - Review article
C2 - 12778333
AN - SCOPUS:0038011861
SN - 0344-4325
VL - 24
SP - 363
EP - 375
JO - Springer Seminars in Immunopathology
JF - Springer Seminars in Immunopathology
IS - 4
ER -