The role of B cells in lpr/lpr-induced autoimmunity

Mark J. Shlomchik, Michael P. Madaio, Donghui Ni, Mary Trounstein, Dennis Huszar

Research output: Contribution to journalArticlepeer-review

194 Scopus citations


The primary roles of T cells and B cells in the initiation of systemic autoimmunity are unclear. To investigate the role of B cells, we crossed the 'Jh knockout' mutation onto the autoimmune lpr/lpr background. Animals homozygous for both traits were obtained. As expected, these animals lack B cells. These animals also show no signs of autoimmune kidney destruction nor vasculitis, in spite of carrying the lpr/lpr mutation. In contrast, lpr/lpr littermates that had B cells had severe nephritis and vasculitis, as well as autoantibodies. These results demonstrate a primary role for B cells and/or (auto)antibodies in initiating several types of autoimmune-mediated tissue destruction. The implications of this finding for models and therapy of autoimmunity are discussed.

Original languageEnglish (US)
Pages (from-to)1295-1306
Number of pages12
JournalJournal of Experimental Medicine
Issue number4
StatePublished - Oct 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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