The role of magnesium in the pathophysiology and treatment of stroke and other neurological injuries

Michael R. Hoane

doi:10.1007/978-1-4419-9663-3_21

The role of magnesium in the pathophysiology and treatment of stroke and other neurological injuries

Michael R. Hoane

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Although there are many compounds that may be beneficial for the treatment of various neurological injuries (ischemic or traumatic) there is but one, Mg²⁺, that has had a rich and controversial history. The physiological investigation of the role of Mg²+ in medicine has had a long history. However, it might come as a surprise that the history of the role of Mg²+ in the pathophysiology of neurological injuries is well over two decades old. The focus of this chapter is to review the available literature on the effects of Mg^{2 +} on the pathophysiology and behavioral recovery from neurological injuries. In addition, data from our laboratory will be presented that has investigated the effects of Mg^{2 +} therapy on recovery of function in the traumatically injured brain.

Original language	English (US)
Title of host publication	Metal Ion in Stroke
Publisher	Springer New York
Pages	431-444
Number of pages	14
ISBN (Electronic)	9781441996633
ISBN (Print)	9781441996626
DOIs	https://doi.org/10.1007/978-1-4419-9663-3_21
State	Published - Jan 1 2012
Externally published	Yes

Keywords

Behavior
Rat
Recovery of function
Stroke
Traumatic brain injury

ASJC Scopus subject areas

General Medicine
General Neuroscience

Access to Document

10.1007/978-1-4419-9663-3_21

Cite this

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abstract = "Although there are many compounds that may be beneficial for the treatment of various neurological injuries (ischemic or traumatic) there is but one, Mg2+, that has had a rich and controversial history. The physiological investigation of the role of Mg2+ in medicine has had a long history. However, it might come as a surprise that the history of the role of Mg2+ in the pathophysiology of neurological injuries is well over two decades old. The focus of this chapter is to review the available literature on the effects of Mg2 + on the pathophysiology and behavioral recovery from neurological injuries. In addition, data from our laboratory will be presented that has investigated the effects of Mg2 + therapy on recovery of function in the traumatically injured brain.",

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AB - Although there are many compounds that may be beneficial for the treatment of various neurological injuries (ischemic or traumatic) there is but one, Mg2+, that has had a rich and controversial history. The physiological investigation of the role of Mg2+ in medicine has had a long history. However, it might come as a surprise that the history of the role of Mg2+ in the pathophysiology of neurological injuries is well over two decades old. The focus of this chapter is to review the available literature on the effects of Mg2 + on the pathophysiology and behavioral recovery from neurological injuries. In addition, data from our laboratory will be presented that has investigated the effects of Mg2 + therapy on recovery of function in the traumatically injured brain.

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ER -

The role of magnesium in the pathophysiology and treatment of stroke and other neurological injuries

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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