The role of platelets in acute lung injury (ALI)

Alexander Zarbock, Klaus Ley

Research output: Contribution to journalArticlepeer-review

99 Scopus citations


Acute lung injury (ALI) is a common syndrome associated with a high mortality rate. Better understanding of the pathophysiology of acute lung injury and progress in supportive care and mechanical ventilation have led to slightly improved clinical outcomes. New evidence shows that the interplay between platelets, leukocytes and endothelial cells is critical in the pathogenesis of ALI. Key molecules involved in this interaction include P-selectin and the eicosanoid thromboxane A2 (TXA2), suggesting potential new targets for pharmacological intervention. In this review, we summarize the aspects of the interactions between platelets, leukocytes, and endothelial cells that are relevant for the pathogenesis of ALI.

Original languageEnglish (US)
Pages (from-to)150-158
Number of pages9
JournalFrontiers in Bioscience
Issue number1
StatePublished - Jan 1 2009
Externally publishedYes


  • Acute lung injury
  • Leukocytes
  • Platelets
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)


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