TY - JOUR
T1 - The role of sirolimus in the prevention of cutaneous squamous cell carcinoma in organ transplant recipients
AU - LeBlanc, Keith G.
AU - Hughes, Matthew P.
AU - Sheehan, Daniel J.
PY - 2011/6
Y1 - 2011/6
N2 - Skin cancers are common in organ transplant recipients (OTRs). In this review, we discuss the epidemiology of and risk factors for cutaneous neoplasms, particularly squamous cell carcinoma (SCC) in OTRs. The pathogenesis of SCC is reviewed, as well as the potential mechanisms for tumor progression and metastasis associated with two commonly used immunosuppressive medications: tacrolimus and cyclosporine. Finally, we discuss the mechanism of action and potential preventative use of sirolimus, a member of a newer class of immunosuppressants, the mammalian target of rapamycin inhibitors.
AB - Skin cancers are common in organ transplant recipients (OTRs). In this review, we discuss the epidemiology of and risk factors for cutaneous neoplasms, particularly squamous cell carcinoma (SCC) in OTRs. The pathogenesis of SCC is reviewed, as well as the potential mechanisms for tumor progression and metastasis associated with two commonly used immunosuppressive medications: tacrolimus and cyclosporine. Finally, we discuss the mechanism of action and potential preventative use of sirolimus, a member of a newer class of immunosuppressants, the mammalian target of rapamycin inhibitors.
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U2 - 10.1111/j.1524-4725.2011.01973.x
DO - 10.1111/j.1524-4725.2011.01973.x
M3 - Review article
C2 - 21605234
AN - SCOPUS:79959855318
SN - 1076-0512
VL - 37
SP - 744
EP - 749
JO - Dermatologic Surgery
JF - Dermatologic Surgery
IS - 6
ER -