Abstract
Skin cancers are common in organ transplant recipients (OTRs). In this review, we discuss the epidemiology of and risk factors for cutaneous neoplasms, particularly squamous cell carcinoma (SCC) in OTRs. The pathogenesis of SCC is reviewed, as well as the potential mechanisms for tumor progression and metastasis associated with two commonly used immunosuppressive medications: tacrolimus and cyclosporine. Finally, we discuss the mechanism of action and potential preventative use of sirolimus, a member of a newer class of immunosuppressants, the mammalian target of rapamycin inhibitors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 744-749 |
| Number of pages | 6 |
| Journal | Dermatologic Surgery |
| Volume | 37 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 2011 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
ASJC Scopus subject areas
- Surgery
- Dermatology
Fingerprint
Dive into the research topics of 'The role of sirolimus in the prevention of cutaneous squamous cell carcinoma in organ transplant recipients'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS