TY - JOUR
T1 - The role of tumor suppressor short non-coding RNAs on breast cancer
AU - Salimimoghadam, Shokooh
AU - Taefehshokr, Sina
AU - Loveless, Reid
AU - Teng, Yong
AU - Bertoli, Gloria
AU - Taefehshokr, Nima
AU - Musaviaroo, Fatemeh
AU - Hajiasgharzadeh, Khalil
AU - Baradaran, Behzad
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2021/2
Y1 - 2021/2
N2 - Characterized by remarkable levels of aggression and malignancy, BC remains one of the leading causes of death in females world wide. Accordingly, significant efforts have been made to develop early diagnostic tools, increase treatment efficacy, and improve patient prognosis. Hopefully, many of the molecular mechanisms underlying BC have been detected and show promising targeting potential. In particular, short and long non-coding RNAs (ncRNAs) are a class of endogenous BC controllers and include a number of different species including microRNAs, Piwi-interacting RNAs, small nucleolar RNA, short interfering RNAs, and tRNA-derivatives. In this review, we discuss the tumor suppressing roles of ncRNAs in the context of BC, and the mechanisms by which ncRNAs target tumor hallmarks, including apoptosis, proliferation, invasion, metastasis, epithelial-mesenchymal transition, angiogenesis, and cell cycle progression, in addition to their diagnostic and prognostic significance in cancer treatment.
AB - Characterized by remarkable levels of aggression and malignancy, BC remains one of the leading causes of death in females world wide. Accordingly, significant efforts have been made to develop early diagnostic tools, increase treatment efficacy, and improve patient prognosis. Hopefully, many of the molecular mechanisms underlying BC have been detected and show promising targeting potential. In particular, short and long non-coding RNAs (ncRNAs) are a class of endogenous BC controllers and include a number of different species including microRNAs, Piwi-interacting RNAs, small nucleolar RNA, short interfering RNAs, and tRNA-derivatives. In this review, we discuss the tumor suppressing roles of ncRNAs in the context of BC, and the mechanisms by which ncRNAs target tumor hallmarks, including apoptosis, proliferation, invasion, metastasis, epithelial-mesenchymal transition, angiogenesis, and cell cycle progression, in addition to their diagnostic and prognostic significance in cancer treatment.
KW - Apoptosis
KW - BC
KW - Metastasis
KW - Small non-coding RNA
KW - miRNA
KW - piRNA
KW - siRNA
KW - snoRNA
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U2 - 10.1016/j.critrevonc.2020.103210
DO - 10.1016/j.critrevonc.2020.103210
M3 - Review article
C2 - 33385514
AN - SCOPUS:85099253765
SN - 1040-8428
VL - 158
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
M1 - 103210
ER -