TY - JOUR
T1 - Theophylline therapy for near-fatal cheyne-stokes respiration. A case report
AU - Pesek, Catherine A.
AU - Cooley, Ryan
AU - Narkiewicz, Krzysztof
AU - Dyken, Mark
AU - Weintraub, Neal L.
AU - Somers, Virend K.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1999/3/2
Y1 - 1999/3/2
N2 - Background: Cheyne-Stokes respiration is characterized by periodic breathing that alternates with hypopnea or apnea. Objective: To describe the effect of theophylline on near-fatal Cheyne-Stokes respiration. Design: Case report. Setting: Tertiary referral center. Patient: A 48-year-old diabetic woman with a history of three cardiorespiratory arrests, a normal coronary arteriogram, normal left ventricular function, and severe Cheyne-Stokes respiration. Measurements: Oxygen saturation, intra-arterial blood pressure, central venous pressure, chest wall movement, electrocardiography, electromyography, electroencephalography, electro-oculography, minute ventilation, arterial blood gases, and serum theophylline levels. Results: After intravenous administration of 1.2 mg of theophylline at 0.6 mg/kg per hour (serum level, 5.6 μg/ mL), both Cheyne-Stokes respiration and oxygen desaturation were markedly attenuated. After infusion of 2.4 mg of theophylline (serum level, 11.6 μg/mL), Cheyne-Stokes respiration resolved completely. No change was seen with placebo. Cheyne-Stokes respiration did not recur during outpatient treatment with oral theophylline. Conclusion: Theophylline may be a rapid and effective therapy for life-threatening Cheyne-Stokes respiration.
AB - Background: Cheyne-Stokes respiration is characterized by periodic breathing that alternates with hypopnea or apnea. Objective: To describe the effect of theophylline on near-fatal Cheyne-Stokes respiration. Design: Case report. Setting: Tertiary referral center. Patient: A 48-year-old diabetic woman with a history of three cardiorespiratory arrests, a normal coronary arteriogram, normal left ventricular function, and severe Cheyne-Stokes respiration. Measurements: Oxygen saturation, intra-arterial blood pressure, central venous pressure, chest wall movement, electrocardiography, electromyography, electroencephalography, electro-oculography, minute ventilation, arterial blood gases, and serum theophylline levels. Results: After intravenous administration of 1.2 mg of theophylline at 0.6 mg/kg per hour (serum level, 5.6 μg/ mL), both Cheyne-Stokes respiration and oxygen desaturation were markedly attenuated. After infusion of 2.4 mg of theophylline (serum level, 11.6 μg/mL), Cheyne-Stokes respiration resolved completely. No change was seen with placebo. Cheyne-Stokes respiration did not recur during outpatient treatment with oral theophylline. Conclusion: Theophylline may be a rapid and effective therapy for life-threatening Cheyne-Stokes respiration.
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U2 - 10.7326/0003-4819-130-5-199903020-00014
DO - 10.7326/0003-4819-130-5-199903020-00014
M3 - Article
C2 - 10068417
AN - SCOPUS:0033515105
SN - 0003-4819
VL - 130
SP - 427
EP - 430
JO - Annals of internal medicine
JF - Annals of internal medicine
IS - 5
ER -