Abstract
Objective and importance: Therapy-related myelodysplastic syndrome (t-MDS) is a rare and typically fatal complication of therapy for cancer, including brain tumors. We report successful therapy of t-MDS that developed after treatment for an anaplastic astrocytoma. Clinical presentation: t-MDS developed four and one-half years after successful therapy (resection, radiation and chemotherapy) administered for a cerebral anaplastic astrocytoma in a 34-year-old patient. Intervention: The patient was treated with allogeneic bone marrow transplant (BMT) for t-MDS. Conclusion: She is alive three years after BMT with no evidence of brain tumor and in complete remission from t-MDS. To our knowledge, this is the first report of allogeneic BMT administered for t-MDS in an adult brain tumor patient. Clinicians must be alert to the development of t-MDS following chemotherapy for brain tumors and initiate appropriate treatment promptly.
Original language | English (US) |
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Pages (from-to) | 55-59 |
Number of pages | 5 |
Journal | Journal of Neuro-Oncology |
Volume | 53 |
Issue number | 1 |
DOIs | |
State | Published - 2001 |
Externally published | Yes |
Keywords
- Antineoplastic agents
- Brain neoplasms
- Leukemia
- Myelodysplastic syndromes
ASJC Scopus subject areas
- Oncology
- Neurology
- Clinical Neurology
- Cancer Research