Thermodynamic-geometric correlations for the morphology of self-assembled structures of glycosphingolipids and their mixtures with dipalmitoylphosphatidylcholine

Bruno Maggio; John Albert; Robert K. Yu

doi:10.1016/0005-2736(88)90477-4

Thermodynamic-geometric correlations for the morphology of self-assembled structures of glycosphingolipids and their mixtures with dipalmitoylphosphatidylcholine

Bruno Maggio, John Albert, Robert K. Yu

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

The morphology of aqueous dispersions of five neutral glycosphingolipids (GalCer, GlcCer, LacCer, asialo-G_M2, asialo-G_M1), sulfatide, and five gangliosides (G_M3, G_M2, G_M1, G_D1a and G_t1b) and their mixtures with dipalmitoylphosphatidylcholine was studied by negative staining electron microscopy. The morphological features are interpreted on the basis of thermodynamic and geometric constraints previously studied in these systems (Maggio, B (1985) Biochim. Biophys. Acta 815, 245-258). The correlation between the theoretical predictions and the experimental findings are in reasonable agreement. Small changes in tge molecular parameters of the individual glycosphingolipids or in their proportion in mixtures with dipalmitoylphosphatidylcholine bring about remarkable variations on the type of structure formed, its radius of curvature and thermodynamic stability.

Original language	English (US)
Pages (from-to)	145-160
Number of pages	16
Journal	BBA - Biomembranes
Volume	945
Issue number	2
DOIs	https://doi.org/10.1016/0005-2736(88)90477-4
State	Published - Nov 22 1988
Externally published	Yes

Keywords

Dipalmitoylphosphatidylcholine
Ganglioside
Geometrics
Glycosphingolipid
Membrane morphology
Thermodynamics

ASJC Scopus subject areas

Biophysics
Biochemistry
Cell Biology

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10.1016/0005-2736(88)90477-4

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title = "Thermodynamic-geometric correlations for the morphology of self-assembled structures of glycosphingolipids and their mixtures with dipalmitoylphosphatidylcholine",

abstract = "The morphology of aqueous dispersions of five neutral glycosphingolipids (GalCer, GlcCer, LacCer, asialo-GM2, asialo-GM1), sulfatide, and five gangliosides (GM3, GM2, GM1, GD1a and Gt1b) and their mixtures with dipalmitoylphosphatidylcholine was studied by negative staining electron microscopy. The morphological features are interpreted on the basis of thermodynamic and geometric constraints previously studied in these systems (Maggio, B (1985) Biochim. Biophys. Acta 815, 245-258). The correlation between the theoretical predictions and the experimental findings are in reasonable agreement. Small changes in tge molecular parameters of the individual glycosphingolipids or in their proportion in mixtures with dipalmitoylphosphatidylcholine bring about remarkable variations on the type of structure formed, its radius of curvature and thermodynamic stability.",

keywords = "Dipalmitoylphosphatidylcholine, Ganglioside, Geometrics, Glycosphingolipid, Membrane morphology, Thermodynamics",

author = "Bruno Maggio and John Albert and Yu, {Robert K.}",

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T1 - Thermodynamic-geometric correlations for the morphology of self-assembled structures of glycosphingolipids and their mixtures with dipalmitoylphosphatidylcholine

AU - Maggio, Bruno

AU - Albert, John

AU - Yu, Robert K.

PY - 1988/11/22

Y1 - 1988/11/22

N2 - The morphology of aqueous dispersions of five neutral glycosphingolipids (GalCer, GlcCer, LacCer, asialo-GM2, asialo-GM1), sulfatide, and five gangliosides (GM3, GM2, GM1, GD1a and Gt1b) and their mixtures with dipalmitoylphosphatidylcholine was studied by negative staining electron microscopy. The morphological features are interpreted on the basis of thermodynamic and geometric constraints previously studied in these systems (Maggio, B (1985) Biochim. Biophys. Acta 815, 245-258). The correlation between the theoretical predictions and the experimental findings are in reasonable agreement. Small changes in tge molecular parameters of the individual glycosphingolipids or in their proportion in mixtures with dipalmitoylphosphatidylcholine bring about remarkable variations on the type of structure formed, its radius of curvature and thermodynamic stability.

AB - The morphology of aqueous dispersions of five neutral glycosphingolipids (GalCer, GlcCer, LacCer, asialo-GM2, asialo-GM1), sulfatide, and five gangliosides (GM3, GM2, GM1, GD1a and Gt1b) and their mixtures with dipalmitoylphosphatidylcholine was studied by negative staining electron microscopy. The morphological features are interpreted on the basis of thermodynamic and geometric constraints previously studied in these systems (Maggio, B (1985) Biochim. Biophys. Acta 815, 245-258). The correlation between the theoretical predictions and the experimental findings are in reasonable agreement. Small changes in tge molecular parameters of the individual glycosphingolipids or in their proportion in mixtures with dipalmitoylphosphatidylcholine bring about remarkable variations on the type of structure formed, its radius of curvature and thermodynamic stability.

KW - Dipalmitoylphosphatidylcholine

KW - Ganglioside

KW - Geometrics

KW - Glycosphingolipid

KW - Membrane morphology

KW - Thermodynamics

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DO - 10.1016/0005-2736(88)90477-4

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AN - SCOPUS:0024294833

SN - 0005-2736

VL - 945

SP - 145

EP - 160

JO - BBA - Biomembranes

JF - BBA - Biomembranes

IS - 2

ER -

Thermodynamic-geometric correlations for the morphology of self-assembled structures of glycosphingolipids and their mixtures with dipalmitoylphosphatidylcholine

Abstract

Keywords

ASJC Scopus subject areas

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