Third-hand Smoke: Impact on Hemostasis and Thrombogenesis

Zubair A. Karim, Fatima Z. Alshbool, Hari Priya Vemana, Neema Adhami, Sandeep Dhall, Enma V.P. Espinosa, Manuela Martins-Green, Fadi T. Khasawneh

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Cigarette smoking is a major risk factor for acute coronary thrombosis. In fact, both active/first-hand smoke and passive/second-hand smoke exposure are known to increase the risk of coronary thrombosis. Although recently a new risk has been identified and termed third-hand smoke (THS), which is the residual tobacco smoke contaminant that remains after a cigarette is extinguished, it remains to be determined whether it can also enhance the risk of thrombogenesis, much like first-hand smoke and second-hand smoke. Therefore, the present studies investigated the impact of THS exposure in the context of platelet biology and related disease states. It was found that THS-exposed mice exhibited an enhanced platelet aggregation and secretion responses as well as enhanced integrin GPIIb-IIIa activation. Furthermore, it was found that THS exposure shortens the tail bleeding time and the occlusion time in a model of thrombosis. Thus, our data demonstrate for the first time (at least in mice) that THS exposure increases the risk of thrombosis-based disease states, which is attributed, at least in part, to their hyperactive platelets.

Original languageEnglish (US)
Pages (from-to)177-182
Number of pages6
JournalJournal of Cardiovascular Pharmacology
Issue number2
StatePublished - Aug 21 2015
Externally publishedYes


  • hemostasis
  • Platelet
  • third-hand smoke
  • thrombogenesis
  • tobacco

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine


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