Three properties of SARS-CoV-2 that promote COVID-19

Ken S. Rosenthal

doi:10.1097/IPC.0000000000000941

Three properties of SARS-CoV-2 that promote COVID-19

Ken S. Rosenthal

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Much of COVID-19 disease can be attributed to the stable structure of the envelope, which facilitates its transmission; the spike protein and its receptor which determine which tissues get infected and are susceptible to viral and immune cytolysis; and evasion of initiation of type 1 and 3 interferons, which gives the virus a replicative head start and ability to spread while simultaneously compromising the antiviral immune response.

Original language	English (US)
Pages (from-to)	324-326
Number of pages	3
Journal	Infectious Diseases in Clinical Practice
Volume	28
Issue number	6
DOIs	https://doi.org/10.1097/IPC.0000000000000941
State	Published - Nov 1 2020
Externally published	Yes

Keywords

COVID-19
SARS CoV-2
type 1 interferon
type 3 interferon

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1097/IPC.0000000000000941

Cite this

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title = "Three properties of SARS-CoV-2 that promote COVID-19",

abstract = "Much of COVID-19 disease can be attributed to the stable structure of the envelope, which facilitates its transmission; the spike protein and its receptor which determine which tissues get infected and are susceptible to viral and immune cytolysis; and evasion of initiation of type 1 and 3 interferons, which gives the virus a replicative head start and ability to spread while simultaneously compromising the antiviral immune response.",

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AB - Much of COVID-19 disease can be attributed to the stable structure of the envelope, which facilitates its transmission; the spike protein and its receptor which determine which tissues get infected and are susceptible to viral and immune cytolysis; and evasion of initiation of type 1 and 3 interferons, which gives the virus a replicative head start and ability to spread while simultaneously compromising the antiviral immune response.

KW - COVID-19

KW - SARS CoV-2

KW - type 1 interferon

KW - type 3 interferon

UR - https://www.scopus.com/pages/publications/85096224032

UR - https://www.scopus.com/pages/publications/85096224032#tab=citedBy

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M3 - Review article

AN - SCOPUS:85096224032

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EP - 326

JO - Infectious Diseases in Clinical Practice

JF - Infectious Diseases in Clinical Practice

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ER -

Three properties of SARS-CoV-2 that promote COVID-19

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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