Thyroid hormone can restore the audiogenic seizure susceptibility of hypothyroid DBA 2J mice

Thomas N. Seyfried; Gilbert H. Glaser; Robert K. Yu

doi:10.1016/0014-4886(81)90083-2

Thyroid hormone can restore the audiogenic seizure susceptibility of hypothyroid DBA 2J mice

Thomas N. Seyfried, Gilbert H. Glaser, Robert K. Yu

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7 Scopus citations

Abstract

The audiogenic seizure (AS) susceptibility of DBA 2J (D2) mice could be suppressed by administration of the antithyroid drug 6-n-propyl-2-thiouracil from 3 days before birth until the time of AS testing (19 days after birth). This treatment effectively induced hypothyroidism. The AS susceptibility of these mice, however, could be almost completely restored by thyroxine replacement from postnatal day 1 through postnatal day 17. The restoration of AS susceptibility by thyroxine replacement was not accompanied by a corresponding restoration of normal serum thyroxine and estimated free thyroxine levels. These observations suggest that thyroid hormone may influence AS susceptibility at some early critical stage of brain development and may be an important requirement for the development of AS susceptibility in D2 mice.

Original language	English (US)
Pages (from-to)	220-225
Number of pages	6
Journal	Experimental Neurology
Volume	71
Issue number	1
DOIs	https://doi.org/10.1016/0014-4886(81)90083-2
State	Published - Jan 1981
Externally published	Yes

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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10.1016/0014-4886(81)90083-2

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title = "Thyroid hormone can restore the audiogenic seizure susceptibility of hypothyroid DBA 2J mice",

abstract = "The audiogenic seizure (AS) susceptibility of DBA 2J (D2) mice could be suppressed by administration of the antithyroid drug 6-n-propyl-2-thiouracil from 3 days before birth until the time of AS testing (19 days after birth). This treatment effectively induced hypothyroidism. The AS susceptibility of these mice, however, could be almost completely restored by thyroxine replacement from postnatal day 1 through postnatal day 17. The restoration of AS susceptibility by thyroxine replacement was not accompanied by a corresponding restoration of normal serum thyroxine and estimated free thyroxine levels. These observations suggest that thyroid hormone may influence AS susceptibility at some early critical stage of brain development and may be an important requirement for the development of AS susceptibility in D2 mice.",

author = "Seyfried, {Thomas N.} and Glaser, {Gilbert H.} and Yu, {Robert K.}",

note = "Funding Information: 1 This work was supported by grants from the U.S. Public Health Service (NS11853) and the Swebilius Fund. Dr. Seyfried is the recipient of a Research Career Development Award (lKO4NSOO59) from the U.S. Public Health Service.",

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doi = "10.1016/0014-4886(81)90083-2",

language = "English (US)",

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journal = "Experimental Neurology",

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T1 - Thyroid hormone can restore the audiogenic seizure susceptibility of hypothyroid DBA 2J mice

AU - Seyfried, Thomas N.

AU - Glaser, Gilbert H.

AU - Yu, Robert K.

N1 - Funding Information: 1 This work was supported by grants from the U.S. Public Health Service (NS11853) and the Swebilius Fund. Dr. Seyfried is the recipient of a Research Career Development Award (lKO4NSOO59) from the U.S. Public Health Service.

PY - 1981/1

Y1 - 1981/1

N2 - The audiogenic seizure (AS) susceptibility of DBA 2J (D2) mice could be suppressed by administration of the antithyroid drug 6-n-propyl-2-thiouracil from 3 days before birth until the time of AS testing (19 days after birth). This treatment effectively induced hypothyroidism. The AS susceptibility of these mice, however, could be almost completely restored by thyroxine replacement from postnatal day 1 through postnatal day 17. The restoration of AS susceptibility by thyroxine replacement was not accompanied by a corresponding restoration of normal serum thyroxine and estimated free thyroxine levels. These observations suggest that thyroid hormone may influence AS susceptibility at some early critical stage of brain development and may be an important requirement for the development of AS susceptibility in D2 mice.

AB - The audiogenic seizure (AS) susceptibility of DBA 2J (D2) mice could be suppressed by administration of the antithyroid drug 6-n-propyl-2-thiouracil from 3 days before birth until the time of AS testing (19 days after birth). This treatment effectively induced hypothyroidism. The AS susceptibility of these mice, however, could be almost completely restored by thyroxine replacement from postnatal day 1 through postnatal day 17. The restoration of AS susceptibility by thyroxine replacement was not accompanied by a corresponding restoration of normal serum thyroxine and estimated free thyroxine levels. These observations suggest that thyroid hormone may influence AS susceptibility at some early critical stage of brain development and may be an important requirement for the development of AS susceptibility in D2 mice.

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Thyroid hormone can restore the audiogenic seizure susceptibility of hypothyroid DBA 2J mice

Abstract

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