Abstract
Long-term potentiation (LTP) in the hippocampus of awake animals is known to be reversed by long trains of low-frequency stimulation (LFS). Here we show that a persistent LTP reversal, i.e. depotentiation (DP), can be induced in the dentate gyrus of freely moving rats by brief 7 Hz stimulations (three trains of 100 pulses, 1 min intertrain-interval) if LFS was applied 2 min after tetanization. In contrast, the same LFS protocol given 15 min after tetanization failed to induce long-lasting DP. Likewise, reduction of LFS (given 2 min post-tetanus) to two trains resulted only in short-term DP. Because naturally occurring hippocampal 7 Hz oscillatory events are correlated to new sensory input, our results might be relevant for the understanding of the mechanisms of LTP reversal induced by processing new information.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 82-84 |
| Number of pages | 3 |
| Journal | Neuroscience Letters |
| Volume | 339 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 13 2003 |
Keywords
- Dentate gyrus
- Depotentiation
- Hippocampus
- Long-term potentiation
- Low-frequency stimulation
ASJC Scopus subject areas
- Neuroscience(all)