Tissue penetration of clindamycin in diabetic foot infections

Charles Duckworth, John F. Fisher, Sally A. Carter, Cheryl L. Newman, Cindy Cogburn, Robert R. Nesbit, Charles H. Wray

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Serum and tissue samples were obtained during surgery from four diabetics with neuropathy who underwent debridement or amputation for foot infections while receiving cindamycin 600 or 900 mg iv. Clindamycin concentrations were assayed by radioimmunoassay. Clindamycin was detected in all serum and tissue samples (range: 0·04-2·8 mg/kg in tissues and 1·1-11·1 mg/L in serum). In nine of the eleven tissue samples the clindamycin concentration exceeded the MICs reported for many pathogens commonly involved in such infections. In only a single instance was the ratio of tissue to serum concentration < 0·13.

Original languageEnglish (US)
Pages (from-to)581-584
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Issue number4
StatePublished - Apr 1993

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)


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