Abstract
Considering the great physiological and behavioral similarities with humans, monkeys represent the ideal models not only for the study of complex cognitive behavior but also for the preclinical research and development of novel therapeutics for treating human diseases. Various powerful genetic technologies initially developed for making mouse models are being explored for generating transgenic primate models. We review the latest genetic engineering technologies and discuss the potentials and limitations for systematic production of transgenic primates.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 506-514 |
| Number of pages | 9 |
| Journal | Science in China, Series C: Life Sciences |
| Volume | 52 |
| Issue number | 6 |
| DOIs | |
| State | Published - Apr 2009 |
| Externally published | Yes |
Keywords
- Disease model
- Genetics
- Learning
- Memory
- Mouse
- Non-human primate
- Transgene
ASJC Scopus subject areas
- Renewable Energy, Sustainability and the Environment
- Modeling and Simulation
- Biochemistry, Genetics and Molecular Biology(all)
- Fuel Technology
- Environmental Science(all)
- Energy Engineering and Power Technology
- Agricultural and Biological Sciences(all)
- Energy(all)
- Management, Monitoring, Policy and Law
