TY - JOUR
T1 - Traditional uses, phytochemistry and pharmacology of Clerodendron glandulosum Coleb – a review
AU - Jadeja, Ravirajsinh N.
AU - Thounaojam, Menaka C.
AU - Singh, Thouchom Brojendro
AU - Devkar, Ranjitsinh V.
AU - Ramachandran, A. V.
N1 - Funding Information:
Mr. Ravirajsinh N Jadeja wish to acknowledge Council of Scientific and Industrial Research (CSIR), New Delhi, INDIA for providing financial assistant in the form of CSIR-Senior Research Fellowship (Award No. 09/114/(0179)/2011/ EMR-1).
Publisher Copyright:
© 2012 Hainan Medical College
PY - 2012/1
Y1 - 2012/1
N2 - Present review for the first time provides a complete botanical description and information on ethnomedicinal uses of Clerodendron glandulosum.Coleb (CG; Fam, Verbenaceae). Recent studies conducted from our laboratory provide pharmacological evidence for its anti-hypertensive, anti-diabetic and anti-obesity potentials. Further, its beneficial potential in preventing in vitro and in vivo non-alcoholic steatohepatitis and atherosclerosis and potent hepatoprotective and free radical scavenging abilities along with its acute and sub-chronic toxicological evaluations are also reported from our laboratory. In keeping with its traditional uses, CG extract was capable of ameliorating experimentally induced hypertension, diabetes and obesity. Its beneficial potential against NASH induced oxidative stress and atherosclerosis can be attributed to its potent free radical scavenging potential. Non-toxic nature of CG leaf extract further provides added merit to its reported pharmacological properties. The present review summarizes the pioneering scientific evidence for the pharmacological effects of CG against related metabolic disorders like hypertension, diabetes and obesity along with anti oxidant potential and beneficial effects against non alcoholic steatohepatitis.
AB - Present review for the first time provides a complete botanical description and information on ethnomedicinal uses of Clerodendron glandulosum.Coleb (CG; Fam, Verbenaceae). Recent studies conducted from our laboratory provide pharmacological evidence for its anti-hypertensive, anti-diabetic and anti-obesity potentials. Further, its beneficial potential in preventing in vitro and in vivo non-alcoholic steatohepatitis and atherosclerosis and potent hepatoprotective and free radical scavenging abilities along with its acute and sub-chronic toxicological evaluations are also reported from our laboratory. In keeping with its traditional uses, CG extract was capable of ameliorating experimentally induced hypertension, diabetes and obesity. Its beneficial potential against NASH induced oxidative stress and atherosclerosis can be attributed to its potent free radical scavenging potential. Non-toxic nature of CG leaf extract further provides added merit to its reported pharmacological properties. The present review summarizes the pioneering scientific evidence for the pharmacological effects of CG against related metabolic disorders like hypertension, diabetes and obesity along with anti oxidant potential and beneficial effects against non alcoholic steatohepatitis.
KW - Atherosclerosis
KW - Clerodendron glandulosum. Coleb
KW - Hypertension
KW - Insulin resistance
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=84857137037&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857137037&partnerID=8YFLogxK
U2 - 10.1016/S1995-7645(11)60236-8
DO - 10.1016/S1995-7645(11)60236-8
M3 - Article
C2 - 22182635
AN - SCOPUS:84857137037
SN - 1995-7645
VL - 5
SP - 1
EP - 6
JO - Asian Pacific Journal of Tropical Medicine
JF - Asian Pacific Journal of Tropical Medicine
IS - 1
ER -