Traumatic brain injury: A risk factor for neurodegenerative diseases

Rajaneesh Gupta, Nilkantha Sen

Research output: Contribution to journalArticlepeer-review

95 Scopus citations


Traumatic brain injury (TBI), a major global health and socioeconomic problem, is now established as a chronic disease process with a broad spectrum of pathophysiological symptoms followed by long-term disabilities. It triggers multiple and multidirectional biochemical events that lead to neurodegeneration and cognitive impairment. Recent studies have presented strong evidence that patients with TBI history have a tendency to develop proteinopathy, which is the pathophysiological feature of neurodegenerative disorders such as Alzheimer disease (AD), chronic traumatic encephalopathy (CTE), and amyotrophic lateral sclerosis (ALS). This review mainly focuses on mechanisms related to AD, CTE, and ALS that are induced after TBI and their relevance to the advancement of these neurodegenerative diseases. This review encompasses acute effects and chronic neurodegenerative consequences after TBI for a better understanding of TBI-induced neuronal death and to design therapies that will effectively treat patients in the primary or secondary progressive stages.

Original languageEnglish (US)
Pages (from-to)93-100
Number of pages8
JournalReviews in the Neurosciences
Issue number1
StatePublished - Jan 1 2016


  • Alzheimer disease
  • amyotrophic lateral sclerosis
  • chronic traumatic encephalopathy
  • neurodegeneration
  • traumatic brain injury

ASJC Scopus subject areas

  • Neuroscience(all)


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