TY - JOUR
T1 - Traumatic brain injury
T2 - A risk factor for neurodegenerative diseases
AU - Gupta, Rajaneesh
AU - Sen, Nilkantha
N1 - Publisher Copyright:
© 2016 by De Gruyter.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Traumatic brain injury (TBI), a major global health and socioeconomic problem, is now established as a chronic disease process with a broad spectrum of pathophysiological symptoms followed by long-term disabilities. It triggers multiple and multidirectional biochemical events that lead to neurodegeneration and cognitive impairment. Recent studies have presented strong evidence that patients with TBI history have a tendency to develop proteinopathy, which is the pathophysiological feature of neurodegenerative disorders such as Alzheimer disease (AD), chronic traumatic encephalopathy (CTE), and amyotrophic lateral sclerosis (ALS). This review mainly focuses on mechanisms related to AD, CTE, and ALS that are induced after TBI and their relevance to the advancement of these neurodegenerative diseases. This review encompasses acute effects and chronic neurodegenerative consequences after TBI for a better understanding of TBI-induced neuronal death and to design therapies that will effectively treat patients in the primary or secondary progressive stages.
AB - Traumatic brain injury (TBI), a major global health and socioeconomic problem, is now established as a chronic disease process with a broad spectrum of pathophysiological symptoms followed by long-term disabilities. It triggers multiple and multidirectional biochemical events that lead to neurodegeneration and cognitive impairment. Recent studies have presented strong evidence that patients with TBI history have a tendency to develop proteinopathy, which is the pathophysiological feature of neurodegenerative disorders such as Alzheimer disease (AD), chronic traumatic encephalopathy (CTE), and amyotrophic lateral sclerosis (ALS). This review mainly focuses on mechanisms related to AD, CTE, and ALS that are induced after TBI and their relevance to the advancement of these neurodegenerative diseases. This review encompasses acute effects and chronic neurodegenerative consequences after TBI for a better understanding of TBI-induced neuronal death and to design therapies that will effectively treat patients in the primary or secondary progressive stages.
KW - Alzheimer disease
KW - amyotrophic lateral sclerosis
KW - chronic traumatic encephalopathy
KW - neurodegeneration
KW - traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=84952894177&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84952894177&partnerID=8YFLogxK
U2 - 10.1515/revneuro-2015-0017
DO - 10.1515/revneuro-2015-0017
M3 - Article
C2 - 26352199
AN - SCOPUS:84952894177
SN - 0334-1763
VL - 27
SP - 93
EP - 100
JO - Reviews in the Neurosciences
JF - Reviews in the Neurosciences
IS - 1
ER -