Treatment of allergic rhinitis with a new selective H1 antihistamine: terfenadine.

C. E. Buckley, S. J. Klemawesch, S. K. Lucas

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The effectiveness of 60 mg b.i.d. of a novel antihistamine, terfenadine, was compared with an active control, 4 mg t.i.d. of chlorpheniramine, and placebo in 560 patients with seasonal allergic rhinitis. In contrast to the gradual decrease in seasonal symptoms observed over a 7 day period of study in placebo-treated patients, both antihistamines produced a prompt significant decrease in sneezing and rhinorrhea, and a gradual decrease in nasopharyngeal pruritus. Terfenadine-related sedation did not differ from that produced by the placebo and was less than the sedation produced by the active control.

Original languageEnglish (US)
Pages (from-to)63-70
Number of pages8
JournalNew England and regional allergy proceedings
Issue number1
StatePublished - Dec 1 1985

ASJC Scopus subject areas

  • Medicine(all)


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