TY - JOUR
T1 - Treatment of chronic experimental Staphylococcus aureus osteomyelitis with LY146032 and vancomycin
AU - Luu, Q. N.
AU - Buxton, T. B.
AU - Nelson, D. R.
AU - Rissing, John Peter
PY - 1989/6/1
Y1 - 1989/6/1
N2 - LY146032 and vancomycin were compared as therapeutic agents in the treatment of chronic Staphylococcus aureus osteomyelitis in the rat. Quantitative cultures disclosed that one of 16, none of 16, and two of 17 tibiae were sterile from the control, LY146032, and vancomycin groups, respectively. From positive cultures, geometric mean staphylococcal CFU per gram of bone were as follows: control, 5.13±1.58; LY146032, 5.36±0.43 (p=0.57); and vancomycin, 4.33±1.73 (p=0.078). Mean gross pathology was decreased significantly in both treatment groups. LY146032 was no more effective than vancomycin in reducing bacterial counts.
AB - LY146032 and vancomycin were compared as therapeutic agents in the treatment of chronic Staphylococcus aureus osteomyelitis in the rat. Quantitative cultures disclosed that one of 16, none of 16, and two of 17 tibiae were sterile from the control, LY146032, and vancomycin groups, respectively. From positive cultures, geometric mean staphylococcal CFU per gram of bone were as follows: control, 5.13±1.58; LY146032, 5.36±0.43 (p=0.57); and vancomycin, 4.33±1.73 (p=0.078). Mean gross pathology was decreased significantly in both treatment groups. LY146032 was no more effective than vancomycin in reducing bacterial counts.
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U2 - 10.1007/BF01967482
DO - 10.1007/BF01967482
M3 - Article
C2 - 2548867
AN - SCOPUS:0024337540
SN - 0934-9723
VL - 8
SP - 562
EP - 563
JO - European Journal of Clinical Microbiology and Infectious Diseases
JF - European Journal of Clinical Microbiology and Infectious Diseases
IS - 6
ER -
