Treatment-related myelodysplasia/AML in a patient with a history of breast cancer and an oligodendroglioma treated with temozolomide: Case study and review of the literature

Vanita Noronha; Nancy Berliner; Karen K. Ballen; Jill Lacy; Jean Kracher; Joachim Baehring; John W. Henson

doi:10.1215/15228517-2006-003

Treatment-related myelodysplasia/AML in a patient with a history of breast cancer and an oligodendroglioma treated with temozolomide: Case study and review of the literature

Vanita Noronha, Nancy Berliner, Karen K. Ballen, Jill Lacy, Jean Kracher, Joachim Baehring, John W. Henson

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

The emergence of temozolomide as an effective alkylating agent with little acute toxicity or cumulative myelosuppression has led to protracted courses of chemotherapy for many patients with gliomas. Secondary, or treatment-related, myelodysplasia (t-MDS) and acute myelogenous leukemia (t-AML) are life-threatening complications of alkylating chemotherapy and have been reported in patients with primary brain tumors. We describe a case of temozolomide-related t-MDS/AML and discuss the clinical features of this condition. Administration of an alkylating agent in patient populations with long median survivals must be undertaken with an understanding of the potential for this treatment complication.

Original language	English (US)
Pages (from-to)	280-283
Number of pages	4
Journal	Neuro-Oncology
Volume	8
Issue number	3
DOIs	https://doi.org/10.1215/15228517-2006-003
State	Published - Jul 2006
Externally published	Yes

Keywords

Brain neoplasm
Glioblastoma
Myelodysplastic syndrome
Recurrent glioma
Secondary leukemia
Secondary myelodysplastic syndrome
Temozolomide
Treatment complication

ASJC Scopus subject areas

Oncology
Clinical Neurology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1215/15228517-2006-003

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title = "Treatment-related myelodysplasia/AML in a patient with a history of breast cancer and an oligodendroglioma treated with temozolomide: Case study and review of the literature",

abstract = "The emergence of temozolomide as an effective alkylating agent with little acute toxicity or cumulative myelosuppression has led to protracted courses of chemotherapy for many patients with gliomas. Secondary, or treatment-related, myelodysplasia (t-MDS) and acute myelogenous leukemia (t-AML) are life-threatening complications of alkylating chemotherapy and have been reported in patients with primary brain tumors. We describe a case of temozolomide-related t-MDS/AML and discuss the clinical features of this condition. Administration of an alkylating agent in patient populations with long median survivals must be undertaken with an understanding of the potential for this treatment complication.",

keywords = "Brain neoplasm, Glioblastoma, Myelodysplastic syndrome, Recurrent glioma, Secondary leukemia, Secondary myelodysplastic syndrome, Temozolomide, Treatment complication",

author = "Vanita Noronha and Nancy Berliner and Ballen, {Karen K.} and Jill Lacy and Jean Kracher and Joachim Baehring and Henson, {John W.}",

year = "2006",

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T2 - Case study and review of the literature

AU - Noronha, Vanita

AU - Berliner, Nancy

AU - Ballen, Karen K.

AU - Lacy, Jill

AU - Kracher, Jean

AU - Baehring, Joachim

AU - Henson, John W.

PY - 2006/7

Y1 - 2006/7

N2 - The emergence of temozolomide as an effective alkylating agent with little acute toxicity or cumulative myelosuppression has led to protracted courses of chemotherapy for many patients with gliomas. Secondary, or treatment-related, myelodysplasia (t-MDS) and acute myelogenous leukemia (t-AML) are life-threatening complications of alkylating chemotherapy and have been reported in patients with primary brain tumors. We describe a case of temozolomide-related t-MDS/AML and discuss the clinical features of this condition. Administration of an alkylating agent in patient populations with long median survivals must be undertaken with an understanding of the potential for this treatment complication.

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KW - Brain neoplasm

KW - Glioblastoma

KW - Myelodysplastic syndrome

KW - Recurrent glioma

KW - Secondary leukemia

KW - Secondary myelodysplastic syndrome

KW - Temozolomide

KW - Treatment complication

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Treatment-related myelodysplasia/AML in a patient with a history of breast cancer and an oligodendroglioma treated with temozolomide: Case study and review of the literature

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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