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Keyphrases
Safety Study
100%
Pharmacokinetic Study
100%
Myeloid Malignancies
100%
Smoothened Antagonist
100%
PF-04449913
100%
Once-daily
57%
Chronic Myeloid Leukemia
57%
Acute Myeloid Leukemia
42%
Maximum Tolerated Dose
42%
Myelodysplastic Syndrome
42%
Myelofibrosis
42%
Toxic Effects
28%
Clinical Activity
28%
Treatment-related Adverse Events
28%
Recommended Phase 2 Dose
28%
Clinical Trials
14%
Pharmacokinetics
14%
Stem Cell Therapy
14%
Tolerability
14%
Clinical Benefit
14%
Intolerant
14%
Newly Diagnosed
14%
Treatment Options
14%
Pharmacokinetics-pharmacodynamics (PK-PD)
14%
Adult Patients
14%
Untreated Disease
14%
Disease Progression
14%
Myeloid Leukemia
14%
Phase 1 Study
14%
Chronic Phase
14%
Previous Treatment
14%
Italy
14%
Phase II Study
14%
Treatment-related
14%
First Cycle
14%
Chemotherapy Resistance
14%
Cancer Progression
14%
First Dose
14%
Dose Finding
14%
Starting Dose
14%
Hedgehog Signaling Pathway
14%
Dysgeusia
14%
Alopecia
14%
Statistical Design
14%
Blast Phase
14%
Leukemia Stem Cells
14%
Decreased Appetite
14%
Pfizer
14%
3 + 3 Design
14%
Patients with Hematological Malignancies
14%
Hedgehog Antagonist
14%
Pharmacology, Toxicology and Pharmaceutical Science
Acute Myeloid Leukemia
100%
Pharmacokinetics
100%
Maximum Tolerated Dose
100%
Myelodysplastic Syndrome
100%
Myelofibrosis
100%
Disease
66%
Adverse Event
66%
Toxicity
66%
Hedgehog
66%
Chronic Myeloid Leukemia
66%
Chronic Myelomonocytic Leukemia
66%
Clinical Trial
33%
Cancer Growth
33%
Tolerability
33%
Pharmacodynamics
33%
Hematologic Malignancy
33%
Disease Exacerbation
33%
Dysgeusia
33%
Alopecia
33%
Myeloid Leukemia
33%
Decreased Appetite
33%
Medicine and Dentistry
Acute Myeloid Leukemia
100%
Pharmacokinetics
100%
Myelodysplastic Syndrome
100%
Myelofibrosis
100%
Myeloid Malignancy
100%
Adverse Event
66%
Disease
66%
Toxicity
66%
Chronic Myelomonocytic Leukemia
66%
Chronic Myelogenous Leukemia
66%
Clinical Trial
33%
Cancer Growth
33%
Stem Cell
33%
Signal Transduction
33%
Myeloid Leukemia
33%
Hematologic Malignancy
33%
Disease Exacerbation
33%
Parageusia
33%
Alopecia Mucinosa
33%
Hedgehog Signaling
33%
Pharmacodynamics
33%
Decreased Appetite
33%