Tregs strip dendritic cells of CD70 to regulate Th1 differentiation

Lukasz Wojciech; Leszek Ignatowicz

doi:10.15252/embj.201591547

Tregs strip dendritic cells of CD70 to regulate Th1 differentiation

Lukasz Wojciech, Leszek Ignatowicz

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

When the immune system encounters an antigen, the response can result in the mobilization of effector cells or in tolerance. The outcome is largely dependent on immunosuppressive CD4 T cells that express the transcription factor Foxp3 (Tregs). Yet, how Tregs control different immune effector cells remains elusive. In this issue of The EMBO Journal, Dhainaut et al report on a novel mechanism used by Tregs to prevent differentiation of naïve CD4 T cells to proinflammatory Th1CD4 (Th1) effectors. A recent study reveals a new mechanism by which regulatory T cells suppress excessive inflammatory responses.

Original language	English (US)
Pages (from-to)	1290-1292
Number of pages	3
Journal	EMBO Journal
Volume	34
Issue number	10
DOIs	https://doi.org/10.15252/embj.201591547
State	Published - May 12 2015

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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10.15252/embj.201591547

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Tregs strip dendritic cells of CD70 to regulate Th1 differentiation

Abstract

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