Tregs strip dendritic cells of CD70 to regulate Th1 differentiation

Lukasz Wojciech, Leszek Ignatowicz

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


When the immune system encounters an antigen, the response can result in the mobilization of effector cells or in tolerance. The outcome is largely dependent on immunosuppressive CD4 T cells that express the transcription factor Foxp3 (Tregs). Yet, how Tregs control different immune effector cells remains elusive. In this issue of The EMBO Journal, Dhainaut et al report on a novel mechanism used by Tregs to prevent differentiation of naïve CD4 T cells to proinflammatory Th1CD4 (Th1) effectors. A recent study reveals a new mechanism by which regulatory T cells suppress excessive inflammatory responses.

Original languageEnglish (US)
Pages (from-to)1290-1292
Number of pages3
JournalEMBO Journal
Issue number10
StatePublished - May 12 2015

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)


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