Trigeminal trophic syndrome from stroke: An under-recognized central neuropathic itch syndrome

Ashley R. Curtis, Anne L. Oaklander, Annette Johnson, Gil Yosipovitch

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Trigeminal trophic syndrome (TTS) is the historic name for neuropathic self-induced facial ulceration from abnormal sensory symptoms leading to uncontrolled scratching. Anatomic co-localization of sensory loss (numbness) plus neuropathic itch and pain permits painless scratching. If the itch is severe, some patients will scratch to the point of causing self-injury. Patients may be unaware or may conceal the fact that their lesions are self-induced and thus the diagnosis presents a clinical challenge. Many cases remain undiagnosed, leading to unnecessary and ineffective tests, procedures, and prescribing. We document a patient with a central cause of TTS multiple cerebral vascular accidents and summarize the presentation, pathogenesis, and treatment options.

Original languageEnglish (US)
Pages (from-to)125-128
Number of pages4
JournalAmerican Journal of Clinical Dermatology
Issue number2
StatePublished - 2012


  • Cerebral-infarction
  • Imaging
  • Neuropathic-pain
  • Pruritus
  • Self-injurious-behavior.
  • Stroke
  • Trigeminal-neuralgia

ASJC Scopus subject areas

  • Dermatology


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