True one cell chemical analysis: A review

Imesha W. De Silva; Amanda R. Kretsch; Holly May Lewis; Melanie Bailey; Guido F. Verbeck

doi:10.1039/c9an00558g

True one cell chemical analysis: A review

Imesha W. De Silva
, Amanda R. Kretsch
, Holly May Lewis
, Melanie Bailey
, Guido F. Verbeck

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The constantly growing field of True One Cell (TOC) analysis has provided important information on the direct chemical composition of various cells and cellular components. Since the heterogeneity of individual cells has been established, more researchers are interested in the chemical differences between individual cells; TOC is the only form of analysis that can provide this information. This has resulted in the constant development of new technologies and methods. This review highlights the common techniques for micro- and nanomanipulation, Raman spectroscopy, microscopy, and mass spectrometric imaging as they pertain to TOC chemical analysis.

Original language	English (US)
Pages (from-to)	4733-4749
Number of pages	17
Journal	Analyst
Volume	144
Issue number	16
DOIs	https://doi.org/10.1039/c9an00558g
State	Published - Aug 21 2019
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Environmental Chemistry
Spectroscopy
Electrochemistry

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10.1039/c9an00558g

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abstract = "The constantly growing field of True One Cell (TOC) analysis has provided important information on the direct chemical composition of various cells and cellular components. Since the heterogeneity of individual cells has been established, more researchers are interested in the chemical differences between individual cells; TOC is the only form of analysis that can provide this information. This has resulted in the constant development of new technologies and methods. This review highlights the common techniques for micro- and nanomanipulation, Raman spectroscopy, microscopy, and mass spectrometric imaging as they pertain to TOC chemical analysis.",

author = "\{De Silva\}, \{Imesha W.\} and Kretsch, \{Amanda R.\} and Lewis, \{Holly May\} and Melanie Bailey and Verbeck, \{Guido F.\}",

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AU - Kretsch, Amanda R.

AU - Lewis, Holly May

AU - Bailey, Melanie

AU - Verbeck, Guido F.

N1 - Publisher Copyright: © The Royal Society of Chemistry 2019.

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AB - The constantly growing field of True One Cell (TOC) analysis has provided important information on the direct chemical composition of various cells and cellular components. Since the heterogeneity of individual cells has been established, more researchers are interested in the chemical differences between individual cells; TOC is the only form of analysis that can provide this information. This has resulted in the constant development of new technologies and methods. This review highlights the common techniques for micro- and nanomanipulation, Raman spectroscopy, microscopy, and mass spectrometric imaging as they pertain to TOC chemical analysis.

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True one cell chemical analysis: A review

Abstract

ASJC Scopus subject areas

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