Tryptophan catabolism, T cell responses & tissue transplantation: Innovative approaches to regulating immune responses

Andrew L. Mellor; David H. Munn; Phillip Chandler; Derin Keskin; Theodore Johnson; Brendan Marshall Babak Baban; Jeffrey Lee

Tryptophan catabolism, T cell responses & tissue transplantation: Innovative approaches to regulating immune responses

Andrew L. Mellor, David H. Munn, Phillip Chandler, Derin Keskin, Theodore Johnson, Brendan Marshall Babak Baban, Jeffrey Lee

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The method for tyrptophan catabolism, T cells and tissue transplantation which are useful in regulating and promoting adaptive immune responses in mammals are discussed. A hypothesis that cells expressing IDO inhibited T cells activation in response to the antigenic challenge due to local catabolism of the essential amino acid tryptophan was proposed. A model showing that T cells are sensitive to the amount of free tryptophan available during a critical period following antigen simulation was also proposed. It was shown that the cells transfected to express IDO inhibit T cell responses in vitro and in vivo.

Original language	English (US)
Title of host publication	Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products
State	Published - Dec 1 2002
Event	Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products - Atlanta, GA, United States Duration: Oct 13 2002 → Oct 16 2002

Other

Other	Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products
Country/Territory	United States
City	Atlanta, GA
Period	10/13/02 → 10/16/02

ASJC Scopus subject areas

Engineering(all)

Cite this

Tryptophan catabolism, T cell responses & tissue transplantation: Innovative approaches to regulating immune responses. / Mellor, Andrew L.; Munn, David H.; Chandler, Phillip et al.
Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products. 2002.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Mellor, AL, Munn, DH, Chandler, P, Keskin, D, Johnson, T, Baban, BMB & Lee, J 2002, Tryptophan catabolism, T cell responses & tissue transplantation: Innovative approaches to regulating immune responses. in Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products. Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products, Atlanta, GA, United States, 10/13/02.

@inproceedings{c409db8da255473bab4d721cb6fee374,

title = "Tryptophan catabolism, T cell responses & tissue transplantation: Innovative approaches to regulating immune responses",

abstract = "The method for tyrptophan catabolism, T cells and tissue transplantation which are useful in regulating and promoting adaptive immune responses in mammals are discussed. A hypothesis that cells expressing IDO inhibited T cells activation in response to the antigenic challenge due to local catabolism of the essential amino acid tryptophan was proposed. A model showing that T cells are sensitive to the amount of free tryptophan available during a critical period following antigen simulation was also proposed. It was shown that the cells transfected to express IDO inhibit T cell responses in vitro and in vivo.",

author = "Mellor, {Andrew L.} and Munn, {David H.} and Phillip Chandler and Derin Keskin and Theodore Johnson and Baban, {Brendan Marshall Babak} and Jeffrey Lee",

year = "2002",

month = dec,

day = "1",

language = "English (US)",

booktitle = "Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products",

note = "Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products ; Conference date: 13-10-2002 Through 16-10-2002",

}

TY - GEN

T1 - Tryptophan catabolism, T cell responses & tissue transplantation

T2 - Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products

AU - Mellor, Andrew L.

AU - Munn, David H.

AU - Chandler, Phillip

AU - Keskin, Derin

AU - Johnson, Theodore

AU - Baban, Brendan Marshall Babak

AU - Lee, Jeffrey

PY - 2002/12/1

Y1 - 2002/12/1

N2 - The method for tyrptophan catabolism, T cells and tissue transplantation which are useful in regulating and promoting adaptive immune responses in mammals are discussed. A hypothesis that cells expressing IDO inhibited T cells activation in response to the antigenic challenge due to local catabolism of the essential amino acid tryptophan was proposed. A model showing that T cells are sensitive to the amount of free tryptophan available during a critical period following antigen simulation was also proposed. It was shown that the cells transfected to express IDO inhibit T cell responses in vitro and in vivo.

AB - The method for tyrptophan catabolism, T cells and tissue transplantation which are useful in regulating and promoting adaptive immune responses in mammals are discussed. A hypothesis that cells expressing IDO inhibited T cells activation in response to the antigenic challenge due to local catabolism of the essential amino acid tryptophan was proposed. A model showing that T cells are sensitive to the amount of free tryptophan available during a critical period following antigen simulation was also proposed. It was shown that the cells transfected to express IDO inhibit T cell responses in vitro and in vivo.

UR - http://www.scopus.com/inward/record.url?scp=18544413124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18544413124&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:18544413124

BT - Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products

Y2 - 13 October 2002 through 16 October 2002

ER -

Tryptophan catabolism, T cell responses & tissue transplantation: Innovative approaches to regulating immune responses

Abstract

Other

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this