Tryptophan catabolism, T cell responses & tissue transplantation: Innovative approaches to regulating immune responses

Andrew L. Mellor; David H. Munn; Phillip Chandler; Derin Keskin; Theodore Johnson; Brendan Marshall Babak Baban; Jeffrey Lee

Tryptophan catabolism, T cell responses & tissue transplantation: Innovative approaches to regulating immune responses

Andrew L. Mellor, David H. Munn, Phillip Chandler, Derin Keskin, Theodore Johnson, Brendan Marshall Babak Baban, Jeffrey Lee

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The method for tyrptophan catabolism, T cells and tissue transplantation which are useful in regulating and promoting adaptive immune responses in mammals are discussed. A hypothesis that cells expressing IDO inhibited T cells activation in response to the antigenic challenge due to local catabolism of the essential amino acid tryptophan was proposed. A model showing that T cells are sensitive to the amount of free tryptophan available during a critical period following antigen simulation was also proposed. It was shown that the cells transfected to express IDO inhibit T cell responses in vitro and in vivo.

Original language	English (US)
Title of host publication	Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products
State	Published - Dec 1 2002
Event	Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products - Atlanta, GA, United States Duration: Oct 13 2002 → Oct 16 2002

Other

Other	Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products
Country/Territory	United States
City	Atlanta, GA
Period	10/13/02 → 10/16/02

ASJC Scopus subject areas

General Engineering

Cite this

Tryptophan catabolism, T cell responses & tissue transplantation: Innovative approaches to regulating immune responses. / Mellor, Andrew L.; Munn, David H.; Chandler, Phillip et al.
Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products. 2002.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Mellor, AL, Munn, DH, Chandler, P, Keskin, D, Johnson, T, Baban, BMB & Lee, J 2002, Tryptophan catabolism, T cell responses & tissue transplantation: Innovative approaches to regulating immune responses. in Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products. Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products, Atlanta, GA, United States, 10/13/02.

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abstract = "The method for tyrptophan catabolism, T cells and tissue transplantation which are useful in regulating and promoting adaptive immune responses in mammals are discussed. A hypothesis that cells expressing IDO inhibited T cells activation in response to the antigenic challenge due to local catabolism of the essential amino acid tryptophan was proposed. A model showing that T cells are sensitive to the amount of free tryptophan available during a critical period following antigen simulation was also proposed. It was shown that the cells transfected to express IDO inhibit T cell responses in vitro and in vivo.",

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AU - Keskin, Derin

AU - Johnson, Theodore

AU - Baban, Brendan Marshall Babak

AU - Lee, Jeffrey

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N2 - The method for tyrptophan catabolism, T cells and tissue transplantation which are useful in regulating and promoting adaptive immune responses in mammals are discussed. A hypothesis that cells expressing IDO inhibited T cells activation in response to the antigenic challenge due to local catabolism of the essential amino acid tryptophan was proposed. A model showing that T cells are sensitive to the amount of free tryptophan available during a critical period following antigen simulation was also proposed. It was shown that the cells transfected to express IDO inhibit T cell responses in vitro and in vivo.

AB - The method for tyrptophan catabolism, T cells and tissue transplantation which are useful in regulating and promoting adaptive immune responses in mammals are discussed. A hypothesis that cells expressing IDO inhibited T cells activation in response to the antigenic challenge due to local catabolism of the essential amino acid tryptophan was proposed. A model showing that T cells are sensitive to the amount of free tryptophan available during a critical period following antigen simulation was also proposed. It was shown that the cells transfected to express IDO inhibit T cell responses in vitro and in vivo.

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M3 - Conference contribution

AN - SCOPUS:18544413124

BT - Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products

Y2 - 13 October 2002 through 16 October 2002

ER -

Tryptophan catabolism, T cell responses & tissue transplantation: Innovative approaches to regulating immune responses

Abstract

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ASJC Scopus subject areas

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