Abstract
Tumors promote immune suppression and dendritic cells (DCs) play a key role in this. However, signaling networks that program DCs to induce immune suppression are unknown. In our recent study, we showed that tumors activate β-catenin/TCF4 in DCs programming them to a regulatory state, which promotes T regulatory responses while suppresses effector T cell responses. Thus, targeting DCs-β-catenin pathway represents a promising target for anticancer immunotherapy.
Original language | English (US) |
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Journal | OncoImmunology |
Volume | 4 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2 2015 |
Keywords
- Wnt
- cancer immunotherapy
- dendritic cells
- immune suppression
- regulatory T cells
- retionic acid
- β-catenin
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Oncology