Tumour suppressor genes

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Summary: Genes responsible for the hereditary predisposition to a variety of human cancers have now been isolated. Their function seems to be part of complex signalling pathways involved in the control of cellular differentiation and the cell cycle. The presence of a single copy of these genes appears to be sufficient to ensure normal development, i.e. prevents tumorigenesis, and has earned them the name -tumour suppressor genes.

Original languageEnglish (US)
Pages (from-to)693-698
Number of pages6
JournalAnnals of Oncology
Issue number9
StatePublished - Nov 1992
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Oncology


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