Twice-weekly exercise training reduces oxidative stress and proinflammatory cytokine levels in elder women

Ricardo Camões Sampaio, Nivaldo Ribeiro De Moura, Marcelo Paes De Barros, Elaine Hatanaka, Fernanda Bruschi Marinho Priviero, Camila De Moraes

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Aim: Reactive oxygen species and high concentrations of proinflammatory cytokines are related to diseases that are often triggered during the aging process. This study aimed to investigate the effect of moderate-intensity physical exercise, twice a week, on oxidative stress and inflammation biomarkers. Methods: Participants were older women aged 60-70 years, engaged in a moderate-intensity exercise program carried out in 60 minutes sessions, twice a week, for 24 weeks. Exercise sessions consisted of step, resistance and stretch exercises. Thiobarbituric acid reactive substances (TBARS), serum iron and cytokines IL-6, IL-1β and IL-1ra were determined using specific kits. Physical fitness was assessed using tests provided by AAPHERD. A paired t test was performed. Results: Moderate-intensity exercise program provided a reduction in lipid peroxidation (27%) and in the serum release of prooxidant iron ions (40%). Cytokine levels were reduced by 37% for IL-6, 16% for IL-1β and 32% for IL-1ra. Improvements in cardiorespiratory fitness (13%), muscular endurance (11%) and flexibility (12%) were also observed. Conclusion: Diminished redox state and inflammation were obtained using a twice-weekly exercise program. These results have important implications for older adults who are unable or unwilling to attend exercise programs more than twice a week. Moreover, these results could re-establish the minimum exercise activity necessary for obtaining health benefits in the elderly population.

Original languageEnglish (US)
Article numbere101990
JournalMotriz. Revista de Educacao Fisica
Issue number3
StatePublished - 2019
Externally publishedYes


  • Aging
  • Antioxidant
  • Community-based
  • Inflammation
  • Iron
  • Reactive oxygen species

ASJC Scopus subject areas

  • Health(social science)


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