Type I diabetes in an adolescent with common variable immunodeficiency

John E. Moffitt; Margaret F. Guill; Mary Sue Leffell; Edwin W. Ades; C. Lynne Burek; Steven A. Lobel; William H. Hoffman

doi:10.1016/0091-6749(89)90324-2

Type I diabetes in an adolescent with common variable immunodeficiency

John E. Moffitt, Margaret F. Guill, Mary Sue Leffell, Edwin W. Ades, C. Lynne Burek, Steven A. Lobel, William H. Hoffman

Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A male adolescent with common variable immunodeficiency developed type I diabetes approximately 1 year after the initiation of immunoglobulin therapy. Immunologic evaluation revealed decreased numbers of T cells and an intrinsic B cell defect in immunoglobulin production. Lymphocytes from the patient failed to generate normal suppressor activity. There were no insulin or islet cell antibodies present in the patient's serum or in the commercial immunoglobulin preparations he received. The panent's HLA phenotype included HLA-DR3 and 4, placing him genetically at high risk for type I diabetes.

Original language	English (US)
Pages (from-to)	191-196
Number of pages	6
Journal	The Journal of Allergy and Clinical Immunology
Volume	84
Issue number	2
DOIs	https://doi.org/10.1016/0091-6749(89)90324-2
State	Published - Aug 1989

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/0091-6749(89)90324-2

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title = "Type I diabetes in an adolescent with common variable immunodeficiency",

abstract = "A male adolescent with common variable immunodeficiency developed type I diabetes approximately 1 year after the initiation of immunoglobulin therapy. Immunologic evaluation revealed decreased numbers of T cells and an intrinsic B cell defect in immunoglobulin production. Lymphocytes from the patient failed to generate normal suppressor activity. There were no insulin or islet cell antibodies present in the patient's serum or in the commercial immunoglobulin preparations he received. The panent's HLA phenotype included HLA-DR3 and 4, placing him genetically at high risk for type I diabetes.",

author = "Moffitt, {John E.} and Guill, {Margaret F.} and Leffell, {Mary Sue} and Ades, {Edwin W.} and Burek, {C. Lynne} and Lobel, {Steven A.} and Hoffman, {William H.}",

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AU - Moffitt, John E.

AU - Guill, Margaret F.

AU - Leffell, Mary Sue

AU - Ades, Edwin W.

AU - Burek, C. Lynne

AU - Lobel, Steven A.

AU - Hoffman, William H.

PY - 1989/8

Y1 - 1989/8

N2 - A male adolescent with common variable immunodeficiency developed type I diabetes approximately 1 year after the initiation of immunoglobulin therapy. Immunologic evaluation revealed decreased numbers of T cells and an intrinsic B cell defect in immunoglobulin production. Lymphocytes from the patient failed to generate normal suppressor activity. There were no insulin or islet cell antibodies present in the patient's serum or in the commercial immunoglobulin preparations he received. The panent's HLA phenotype included HLA-DR3 and 4, placing him genetically at high risk for type I diabetes.

AB - A male adolescent with common variable immunodeficiency developed type I diabetes approximately 1 year after the initiation of immunoglobulin therapy. Immunologic evaluation revealed decreased numbers of T cells and an intrinsic B cell defect in immunoglobulin production. Lymphocytes from the patient failed to generate normal suppressor activity. There were no insulin or islet cell antibodies present in the patient's serum or in the commercial immunoglobulin preparations he received. The panent's HLA phenotype included HLA-DR3 and 4, placing him genetically at high risk for type I diabetes.

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JO - Journal of Allergy and Clinical Immunology

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Type I diabetes in an adolescent with common variable immunodeficiency

Abstract

ASJC Scopus subject areas

UN SDGs

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