Unraveling the role of genetics in the pathogenesis of diabetic retinopathy

Ashok Kumar Sharma, Maria L. Valle, Connor Beveridge, Yutao Liu, Shruti Sharma

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Diabetic retinopathy (DR) is a microvascular disease of the retina and the leading cause of visual disability in diabetic patients. Genetic factors have shown to play a pivotal role in DR onset, and several candidate genes have been associated with its progression. A literature search was performed to identify the genes known to be associated with DR through linkage analysis, candidate gene association, and genome-wide association studies (GWAS). A further literature search was performed to discover their potential connection with various biological pathways. A total of 65 genes were found and several of these genes belong to major signaling pathways known to play a significant role in DR, including systemic inflammation, angiogenesis, and neurogenesis. A comprehensive analysis presented in this review will be helpful in unraveling the role of genetics in the pathogenesis of DR.

Original languageEnglish (US)
Pages (from-to)534-541
Number of pages8
JournalEye (Basingstoke)
Issue number4
StatePublished - Apr 1 2019

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems


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