TY - JOUR
T1 - Unraveling the role of genetics in the pathogenesis of diabetic retinopathy
AU - Sharma, Ashok Kumar
AU - Valle, Maria L.
AU - Beveridge, Connor
AU - Liu, Yutao
AU - Sharma, Shruti
N1 - Funding Information:
Acknowledgements This research was supported by an NIH/NEI grant to Shruti Sharma at the Augusta University (5R01-EY026936).
Publisher Copyright:
© 2019, The Royal College of Ophthalmologists.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Diabetic retinopathy (DR) is a microvascular disease of the retina and the leading cause of visual disability in diabetic patients. Genetic factors have shown to play a pivotal role in DR onset, and several candidate genes have been associated with its progression. A literature search was performed to identify the genes known to be associated with DR through linkage analysis, candidate gene association, and genome-wide association studies (GWAS). A further literature search was performed to discover their potential connection with various biological pathways. A total of 65 genes were found and several of these genes belong to major signaling pathways known to play a significant role in DR, including systemic inflammation, angiogenesis, and neurogenesis. A comprehensive analysis presented in this review will be helpful in unraveling the role of genetics in the pathogenesis of DR.
AB - Diabetic retinopathy (DR) is a microvascular disease of the retina and the leading cause of visual disability in diabetic patients. Genetic factors have shown to play a pivotal role in DR onset, and several candidate genes have been associated with its progression. A literature search was performed to identify the genes known to be associated with DR through linkage analysis, candidate gene association, and genome-wide association studies (GWAS). A further literature search was performed to discover their potential connection with various biological pathways. A total of 65 genes were found and several of these genes belong to major signaling pathways known to play a significant role in DR, including systemic inflammation, angiogenesis, and neurogenesis. A comprehensive analysis presented in this review will be helpful in unraveling the role of genetics in the pathogenesis of DR.
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U2 - 10.1038/s41433-019-0337-y
DO - 10.1038/s41433-019-0337-y
M3 - Review article
C2 - 30679875
AN - SCOPUS:85060730005
SN - 0950-222X
VL - 33
SP - 534
EP - 541
JO - Transactions of the Ophthalmological Societies of the United Kingdom
JF - Transactions of the Ophthalmological Societies of the United Kingdom
IS - 4
ER -
