Unraveling the role of genetics in the pathogenesis of diabetic retinopathy

Ashok Kumar Sharma; Maria L. Valle; Connor Beveridge; Yutao Liu; Shruti Sharma

doi:10.1038/s41433-019-0337-y

Unraveling the role of genetics in the pathogenesis of diabetic retinopathy

Ashok Kumar Sharma, Maria L. Valle, Connor Beveridge, Yutao Liu, Shruti Sharma

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Diabetic retinopathy (DR) is a microvascular disease of the retina and the leading cause of visual disability in diabetic patients. Genetic factors have shown to play a pivotal role in DR onset, and several candidate genes have been associated with its progression. A literature search was performed to identify the genes known to be associated with DR through linkage analysis, candidate gene association, and genome-wide association studies (GWAS). A further literature search was performed to discover their potential connection with various biological pathways. A total of 65 genes were found and several of these genes belong to major signaling pathways known to play a significant role in DR, including systemic inflammation, angiogenesis, and neurogenesis. A comprehensive analysis presented in this review will be helpful in unraveling the role of genetics in the pathogenesis of DR.

Original language	English (US)
Pages (from-to)	534-541
Number of pages	8
Journal	Eye (Basingstoke)
Volume	33
Issue number	4
DOIs	https://doi.org/10.1038/s41433-019-0337-y
State	Published - Apr 1 2019

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41433-019-0337-y

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title = "Unraveling the role of genetics in the pathogenesis of diabetic retinopathy",

abstract = "Diabetic retinopathy (DR) is a microvascular disease of the retina and the leading cause of visual disability in diabetic patients. Genetic factors have shown to play a pivotal role in DR onset, and several candidate genes have been associated with its progression. A literature search was performed to identify the genes known to be associated with DR through linkage analysis, candidate gene association, and genome-wide association studies (GWAS). A further literature search was performed to discover their potential connection with various biological pathways. A total of 65 genes were found and several of these genes belong to major signaling pathways known to play a significant role in DR, including systemic inflammation, angiogenesis, and neurogenesis. A comprehensive analysis presented in this review will be helpful in unraveling the role of genetics in the pathogenesis of DR.",

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AU - Sharma, Ashok Kumar

AU - Valle, Maria L.

AU - Beveridge, Connor

AU - Liu, Yutao

AU - Sharma, Shruti

PY - 2019/4/1

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N2 - Diabetic retinopathy (DR) is a microvascular disease of the retina and the leading cause of visual disability in diabetic patients. Genetic factors have shown to play a pivotal role in DR onset, and several candidate genes have been associated with its progression. A literature search was performed to identify the genes known to be associated with DR through linkage analysis, candidate gene association, and genome-wide association studies (GWAS). A further literature search was performed to discover their potential connection with various biological pathways. A total of 65 genes were found and several of these genes belong to major signaling pathways known to play a significant role in DR, including systemic inflammation, angiogenesis, and neurogenesis. A comprehensive analysis presented in this review will be helpful in unraveling the role of genetics in the pathogenesis of DR.

AB - Diabetic retinopathy (DR) is a microvascular disease of the retina and the leading cause of visual disability in diabetic patients. Genetic factors have shown to play a pivotal role in DR onset, and several candidate genes have been associated with its progression. A literature search was performed to identify the genes known to be associated with DR through linkage analysis, candidate gene association, and genome-wide association studies (GWAS). A further literature search was performed to discover their potential connection with various biological pathways. A total of 65 genes were found and several of these genes belong to major signaling pathways known to play a significant role in DR, including systemic inflammation, angiogenesis, and neurogenesis. A comprehensive analysis presented in this review will be helpful in unraveling the role of genetics in the pathogenesis of DR.

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Unraveling the role of genetics in the pathogenesis of diabetic retinopathy

Abstract

ASJC Scopus subject areas

UN SDGs

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