Abstract
Diabetes mellitus is associated with disturbed regulation in the microcircuiation. A low-grade vascular inflammation has been implicated in the development of diabetes-related vascular complications, but the underlying molecular mechanisms has not yet been fully elucidated. It is known that eyelooxy genase-2 (COX-2) plays a key role in prostaglandin biosynthesis during the development of inflammation. Recent studies revealed that in diabetes increased synthesis of various prostanoids. vio up-regulation of COX-2, interleres with the regulation of vasomotor function. In this review, we will summarize the current findings regarding the role of COX-2, and COX-2-derived prostanoids in the regulation of vascular lone, as well as the possible underlying mechanisms leading to COX-2 activation in diabetes mellitus.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 52-56 |
| Number of pages | 5 |
| Journal | Pharmacological Reports |
| Volume | 58 |
| Issue number | SUPPL. |
| State | Published - 2006 |
| Externally published | Yes |
Keywords
- Arteriolar tone
- Cyclooxygenase-2
- Diabetes mellitus
- Prostacyclin
- Thromhoxane A
ASJC Scopus subject areas
- Pharmacology
