TY - JOUR
T1 - Update of the decitabine experience in higher risk myelodysplastic syndrome and analysis of prognostic factors associated with outcome
AU - Kantarjian, Hagop M.
AU - O'Brien, Susan
AU - Shan, Jianqin
AU - Aribi, Ahmed
AU - Garcia-Manero, Guilleirmo
AU - Jabbour, Elias
AU - Ravandi, Farhad
AU - Cortes, Jorge
AU - Davisson, Jan
AU - Issa, Jean Pierre
PY - 2007/1/15
Y1 - 2007/1/15
N2 - BACKGROUND. Therapy for patients with myelodysplastic syndrome (MDS) with hypomethylating agents, like decitabine and 5-azacitidine, has produced favorable results. In this study, the authors update their experience with decitabine in patients with MDS and analyze the cytogenetic response patterns and prognostic factors associated with decitabine therapy. METHODS. One hundred fifteen patients with higher risk MDS who received treatment with decitabine were reviewed. Patients received decitabine 100 mg/m2 per course every 4 weeks in 3 different schedules: 1) 20 mg/m2 intravenously daily × 5, 2) 20 mg/m2 subcutaneously daily × 5, and 3) 10 mg/m2 intravenously daily × 10. Decitabine was given for a median of ≥7 courses (range, 1-23 courses). RESULTS. Overall, 80 patients (70%) achieved a response according to the modified International Working Group criteria (IWG): complete response (CR), 40 patients (35%); partial response, 2 patients (2%); bone marrow CR with or without other hematologic improvements (HI), 26 patients (23%); and other HI, 12 patients (10%). Cytopenias were improved in 50% of patients. The median remission duration was 20 months, and the median survival was 22 months. Mortality was 3% at 6 weeks and 7% at 3 months. In a multivariate analysis, poor prognostic factors for achieving IWG CR were MDS (vs chronic myelomonocytic leukemia), longer duration of MDS, and prior MDS therapy. For survival, independent adverse prognostic factors were chromosome 5 and/or 7 abnormalities, older age, and prior MDS therapy (excluding growth factors). CONCLUSIONS. The longer term experience with decitabine in MDS was favorable. Pretreatment prognostic factors may predict the outcome of patients who receive decitabine therapy for MDS.
AB - BACKGROUND. Therapy for patients with myelodysplastic syndrome (MDS) with hypomethylating agents, like decitabine and 5-azacitidine, has produced favorable results. In this study, the authors update their experience with decitabine in patients with MDS and analyze the cytogenetic response patterns and prognostic factors associated with decitabine therapy. METHODS. One hundred fifteen patients with higher risk MDS who received treatment with decitabine were reviewed. Patients received decitabine 100 mg/m2 per course every 4 weeks in 3 different schedules: 1) 20 mg/m2 intravenously daily × 5, 2) 20 mg/m2 subcutaneously daily × 5, and 3) 10 mg/m2 intravenously daily × 10. Decitabine was given for a median of ≥7 courses (range, 1-23 courses). RESULTS. Overall, 80 patients (70%) achieved a response according to the modified International Working Group criteria (IWG): complete response (CR), 40 patients (35%); partial response, 2 patients (2%); bone marrow CR with or without other hematologic improvements (HI), 26 patients (23%); and other HI, 12 patients (10%). Cytopenias were improved in 50% of patients. The median remission duration was 20 months, and the median survival was 22 months. Mortality was 3% at 6 weeks and 7% at 3 months. In a multivariate analysis, poor prognostic factors for achieving IWG CR were MDS (vs chronic myelomonocytic leukemia), longer duration of MDS, and prior MDS therapy. For survival, independent adverse prognostic factors were chromosome 5 and/or 7 abnormalities, older age, and prior MDS therapy (excluding growth factors). CONCLUSIONS. The longer term experience with decitabine in MDS was favorable. Pretreatment prognostic factors may predict the outcome of patients who receive decitabine therapy for MDS.
KW - Chromosome abnormalities
KW - Decitabine
KW - International Prognostic Scoring System
KW - Myelodysplastic syndrome
UR - http://www.scopus.com/inward/record.url?scp=33846236840&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846236840&partnerID=8YFLogxK
U2 - 10.1002/cncr.22376
DO - 10.1002/cncr.22376
M3 - Review article
C2 - 17133405
AN - SCOPUS:33846236840
SN - 0008-543X
VL - 109
SP - 265
EP - 273
JO - Cancer
JF - Cancer
IS - 2
ER -