Abstract
Objective: To assess hysteroscopic findings in patients undergoing IVF-ET who repeatedly failed to conceive despite transfer of good-quality embryos. Design: Prospective, observational study. Setting: Clinical research unit for reproductive medicine in a private clinic. Patient(s): Fifty-five patients with a normal uterine cavity on hysterosalpingography before the initial IVF-ET cycle and two previous failed IVF-ET attempts despite transfer of a minimum of two good-quality embryos on each occasion. Intervention(s): Standard transvaginal ultrasonography and diagnostic and therapeutic hysteroscopy. Main Outcome Measure(s): Endometrial findings on transvaginal ultrasonography and hysteroscopy and outcome of the cycles after surgical hysteroscopy and antibiotic therapy. Result(s): Twenty-five (45%) patients had abnormal endometrial findings and underwent treatment to correct the lesions. All patients underwent a third IVF-ET cycle. Pregnancy (50% vs. 20%) and implantation (19% vs. 5.5%) rates were significantly higher in patients who were treated for uterine abnormalities than in patients who had normal uterine cavities on hysteroscopy. Conclusion(s): The incidence of pathologic findings on hysteroscopy is high in patients with repeated failures of IVF-ET. Evaluation of endometrial integrity by hysteroscopy is highly valuable and should be applied to all such cases.
Original language | English (US) |
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Pages (from-to) | 1371-1375 |
Number of pages | 5 |
Journal | Fertility and sterility |
Volume | 80 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2003 |
Externally published | Yes |
Keywords
- Embryo quality
- Hysteroscopy
- IVF-ET
- Implantation failure
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology