Uterine fibroids and endometrial dysfunction

Sara A. Mohamed, Waseem Khoder, Ayman Al-Hendy

Research output: Chapter in Book/Report/Conference proceedingChapter


Uterine leiomyomas (fibroids) are widely prevalent steroid hormone-dependent benign tumors that cause several female reproductive dysfunctions among them, a restraint to conception and successful outcome of pregnancies. Mounting evidence suggests that leiomyomas have negative influence on endometrial receptivity to blastocyst implantation. Impaired endometrial receptivity is an important contributing factor to implantation failure. This chapter highlights the current information regarding the effects of uterine fibroids on endometrial receptivity and the molecular mechanisms underpinning uterine fibroid pathophysiology and its interaction with determinants of endometrial receptivity. Such information provides insight into the underlying mechanisms of leiomyoma-associated subfertility and provides new venues for basic and translational research. Although the existing data are impressive, many challenges remain and further research is warranted.

Original languageEnglish (US)
Title of host publicationLeiomyomas
Subtitle of host publicationRisk Factors, Clinical Manifestations and Treatment Options
PublisherNova Science Publishers, Inc.
Number of pages21
ISBN (Electronic)9781634636032
ISBN (Print)9781634635844
StatePublished - Jan 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • General Social Sciences


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