TY - JOUR
T1 - Vaccination against atherosclerosis
AU - Kobiyama, Kouji
AU - Saigusa, Ryosuke
AU - Ley, Klaus
N1 - Publisher Copyright:
© 2019
PY - 2019/8
Y1 - 2019/8
N2 - Atherosclerosis is a chronic inflammatory disease that causes most heart attacks and strokes, making it the biggest killer in the world. Although cholesterol-lowering drugs have dramatically reduced these major adverse cardiovascular events, there remains a high residual risk called inflammatory risk. Atherosclerosis has an autoimmune component that can be manipulated by immunologic approaches including vaccination. Vaccination is attractive, because it is antigen-specific, does not impair host defense, and provides long-term protection. Several candidate antigens for atherosclerosis vaccine development have been identified and have been shown to reduce atherosclerosis in animal models. In this review, we focus on two different types of atherosclerosis vaccines: antibody-inducing and regulatory T cell-inducing.
AB - Atherosclerosis is a chronic inflammatory disease that causes most heart attacks and strokes, making it the biggest killer in the world. Although cholesterol-lowering drugs have dramatically reduced these major adverse cardiovascular events, there remains a high residual risk called inflammatory risk. Atherosclerosis has an autoimmune component that can be manipulated by immunologic approaches including vaccination. Vaccination is attractive, because it is antigen-specific, does not impair host defense, and provides long-term protection. Several candidate antigens for atherosclerosis vaccine development have been identified and have been shown to reduce atherosclerosis in animal models. In this review, we focus on two different types of atherosclerosis vaccines: antibody-inducing and regulatory T cell-inducing.
UR - http://www.scopus.com/inward/record.url?scp=85063479318&partnerID=8YFLogxK
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U2 - 10.1016/j.coi.2019.02.008
DO - 10.1016/j.coi.2019.02.008
M3 - Review article
C2 - 30928800
AN - SCOPUS:85063479318
SN - 0952-7915
VL - 59
SP - 15
EP - 24
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
ER -