Vagus nerve stimulation and drug reduction

William O. Tatum IV, K. D. Johnson, S. Goff, J. A. Ferreira, S. R. Benbadis, F. L. Vale

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


The authors prospectively assessed drug reduction and patient satisfaction in 21 patients using vagus nerve stimulation (VNS) for refractory epilepsy and compared results to a case-matched control group with a mean follow-up of 13.2 months. Significant antiepileptic drug (AED) reduction occurred in 9/21 (42.9)% of VNS patients averaging 0.43 AED/patient, with dose reduction in four patients (19.0%). For 12/21 (57.1%) patients not reducing AED, dose reduction occurred in 6/21 (28.6%). Drug and dose reduction of AED is possible in patients using VNS for refractory epilepsy without loss of seizure control and with improved patient satisfaction.

Original languageEnglish (US)
Pages (from-to)561-563
Number of pages3
Issue number4
StatePublished - Feb 27 2001
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


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