TY - JOUR
T1 - Validation of the PLASMIC score at a University Medical Center
AU - Jajosky, Ryan
AU - Floyd, Mark
AU - Thompson, Thomas
AU - Shikle, James
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/8
Y1 - 2017/8
N2 - Background The PLASMIC score was recently described as a convenient tool for predicting ADAMTS13 activity ≤10% in patients with possible thrombotic thrombocytopenic purpura (TTP), while awaiting the results of this send-out test. The purpose of this study was to validate the PLASMIC score at our University Medical Center. Methods Apheresis records were reviewed from 2008 to 2017 to identify patients who received plasma exchange (PLEX) for suspected TTP. The ADAMTS13 activity and PLASMIC scoring criteria were recorded, and the PLASMIC score was calculated. Results Of the 41 patients identified, 20 met inclusion criteria, of which 7 patients had ADAMTS13 activity ≤10%. Intermediate and high PLASMIC scores had 100% sensitivity, 46.2% specificity, 50% positive predictive value (PPV), and 100% negative predictive value (NPV). Conclusion These results are consistent with the original validation study of the PLASMIC score, supporting the efficacy of the PLASMIC score and validating its use at our institution.
AB - Background The PLASMIC score was recently described as a convenient tool for predicting ADAMTS13 activity ≤10% in patients with possible thrombotic thrombocytopenic purpura (TTP), while awaiting the results of this send-out test. The purpose of this study was to validate the PLASMIC score at our University Medical Center. Methods Apheresis records were reviewed from 2008 to 2017 to identify patients who received plasma exchange (PLEX) for suspected TTP. The ADAMTS13 activity and PLASMIC scoring criteria were recorded, and the PLASMIC score was calculated. Results Of the 41 patients identified, 20 met inclusion criteria, of which 7 patients had ADAMTS13 activity ≤10%. Intermediate and high PLASMIC scores had 100% sensitivity, 46.2% specificity, 50% positive predictive value (PPV), and 100% negative predictive value (NPV). Conclusion These results are consistent with the original validation study of the PLASMIC score, supporting the efficacy of the PLASMIC score and validating its use at our institution.
KW - ADAMTS13 activity
KW - Plasma exchange (PLEX)
KW - Thrombotic microangiopathy (TMA)
UR - http://www.scopus.com/inward/record.url?scp=85026489102&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85026489102&partnerID=8YFLogxK
U2 - 10.1016/j.transci.2017.06.006
DO - 10.1016/j.transci.2017.06.006
M3 - Article
C2 - 28764998
AN - SCOPUS:85026489102
SN - 1473-0502
VL - 56
SP - 591
EP - 594
JO - Transfusion and Apheresis Science
JF - Transfusion and Apheresis Science
IS - 4
ER -