Vascular adhesion molecules in atherosclerosis

Elena Galkina, Klaus Ley

Research output: Contribution to journalShort surveypeer-review

621 Scopus citations


Numerous reports document the role of vascular adhesion molecules in the development and progression of atherosclerosis. Recent novel findings in the field of adhesion molecules require an updated summary of current research. In this review, we highlight the role of vascular adhesion molecules including selectins, vascular cell adhesion molecule (VCAM)-1, intercellular adhesion molecule1 (ICAM-1), PECAM-1, JAMs, and connexins in atherosclerosis. The immune system is important in atherosclerosis, and significant efforts are under way to understand the vascular adhesion molecule-dependent mechanisms of immune cell trafficking into healthy and atherosclerosis-prone arterial walls. This review focuses on the role of vascular adhesion molecules in the regulation of immune cell homing during atherosclerosis and discusses future directions that will lead to better understanding of this disease.

Original languageEnglish (US)
Pages (from-to)2292-2301
Number of pages10
JournalArteriosclerosis, thrombosis, and vascular biology
Issue number11
StatePublished - Nov 2007
Externally publishedYes


  • Atherosclerosis
  • Leukocyte
  • Lymphocyte
  • Macrophages
  • Monocyte
  • Pathophysiology
  • Trafficking

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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