Vascular protection to increase the safety of tissue plasminogen activator for stroke

Tauheed Ishrat, Sahar Soliman, Weihua Guan, Mihaela Saler, Susan C. Fagan

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Thrombolytic therapy with tissue plasminogen activator (tPA) remains the most effective treatment for acute ischemic stroke, but can cause vascular damage leading to edema formation and hemorrhagic transformation (HT). In this review, we discuss how tPA contributes to the pathogenesis of vascular damage and highlight evidence to support combination therapy of tPA with pharmacological agents that are vascular protective. There is an unmet need to develop therapeutic interventions which target the underlying mechanisms of vascular damage after acute ischemic stroke in order to prevent HT and improve the safety and impact of tPA.

Original languageEnglish (US)
Pages (from-to)3677-3684
Number of pages8
JournalCurrent Pharmaceutical Design
Issue number25
StatePublished - 2012


  • Blood-brain barrier
  • Hemorrhagic transformation (HT)
  • Ischemic stroke
  • Matrix metalloproteinases (MMPs)
  • Thrombolysis
  • Tissue plasminogen activator (tPA)
  • Vascular protection

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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