Vascular reactivity in hypertension: Altered effect of ouabain

R. C. Webb; D. F. Bohr

doi:10.1007/BF01953743

Vascular reactivity in hypertension: Altered effect of ouabain

R. C. Webb, D. F. Bohr

Research output: Contribution to journal › Article › peer-review

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Abstract

Ouabain inhibits the relaxing effect of Ca²⁺ (but not of Mn²⁺) on contractile responses in tail artery strips isolated from spontaneously hypertensive and normotensive rats. The magnitude of ouabain inhibition was greater in vascular strips from hypertensive rats suggesting a significant difference in basic membrane function in hypertensive vascular smooth muscle.

Original language	English (US)
Pages (from-to)	220-222
Number of pages	3
Journal	Experientia
Volume	36
Issue number	2
DOIs	https://doi.org/10.1007/BF01953743
State	Published - Feb 1980
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/BF01953743

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title = "Vascular reactivity in hypertension: Altered effect of ouabain",

abstract = "Ouabain inhibits the relaxing effect of Ca2+ (but not of Mn2+) on contractile responses in tail artery strips isolated from spontaneously hypertensive and normotensive rats. The magnitude of ouabain inhibition was greater in vascular strips from hypertensive rats suggesting a significant difference in basic membrane function in hypertensive vascular smooth muscle.",

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AB - Ouabain inhibits the relaxing effect of Ca2+ (but not of Mn2+) on contractile responses in tail artery strips isolated from spontaneously hypertensive and normotensive rats. The magnitude of ouabain inhibition was greater in vascular strips from hypertensive rats suggesting a significant difference in basic membrane function in hypertensive vascular smooth muscle.

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Vascular reactivity in hypertension: Altered effect of ouabain

Abstract

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