TY - JOUR
T1 - Vertical bone augmentation with simultaneous implant placement using particulate mineralized bone and mesenchymal stem cells
T2 - A preliminary study in rabbit
AU - Khojasteh, Arash
AU - Eslaminejad, Mohamadreza Baghaban
AU - Nazarian, Hamid
AU - Morad, Golnaz
AU - Dashti, Seyyedeh Ghazaleh
AU - Behnia, Hossein
AU - Stevens, Mark
PY - 2013/2
Y1 - 2013/2
N2 - This study aimed to assess vertical bone augmentation with simultaneous implant placement in rabbit tibiae using particulate mineralized bone/fibrin glue/mesenchymal stem cell. Bone marrow was aspirated from tibiae of five 10-week-old New Zealand White male rabbits. Right and left tibiae of each rabbit were prepared, and a 3-mm protruding implant from tibial bone was placed in each side. Particulate allogenic bone/fibrin glue/mesenchymal stem cell combination was placed around test implants and particulate bone graft/fibrin glue around controls. Two months postoperatively, the animals were euthanized, and sections were prepared for histological analysis. The mean amount of vertical bone length was higher in the experimental group than the control group (2.09 mm vs 1.03 mm; P < .05). New supracrestal trabecular bone formation was also significantly higher in the test group (28.5 ± 4.5% vs 4.3 ± 1.8%; P < .05). Mesenchymal stem cell/particulate allograft/fibrin glue appears to be a promising combination for vertical bone augmentation around simultaneously inserted implants in rabbit tibia.
AB - This study aimed to assess vertical bone augmentation with simultaneous implant placement in rabbit tibiae using particulate mineralized bone/fibrin glue/mesenchymal stem cell. Bone marrow was aspirated from tibiae of five 10-week-old New Zealand White male rabbits. Right and left tibiae of each rabbit were prepared, and a 3-mm protruding implant from tibial bone was placed in each side. Particulate allogenic bone/fibrin glue/mesenchymal stem cell combination was placed around test implants and particulate bone graft/fibrin glue around controls. Two months postoperatively, the animals were euthanized, and sections were prepared for histological analysis. The mean amount of vertical bone length was higher in the experimental group than the control group (2.09 mm vs 1.03 mm; P < .05). New supracrestal trabecular bone formation was also significantly higher in the test group (28.5 ± 4.5% vs 4.3 ± 1.8%; P < .05). Mesenchymal stem cell/particulate allograft/fibrin glue appears to be a promising combination for vertical bone augmentation around simultaneously inserted implants in rabbit tibia.
KW - Bone regeneration
KW - Dental implant
KW - Mesenchymal stem cell
KW - Vertical augmentation
UR - http://www.scopus.com/inward/record.url?scp=84875536851&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875536851&partnerID=8YFLogxK
U2 - 10.1563/AAID-JOI-D-10-00206
DO - 10.1563/AAID-JOI-D-10-00206
M3 - Article
C2 - 21568719
AN - SCOPUS:84875536851
SN - 0160-6972
VL - 39
SP - 3
EP - 13
JO - Journal of Oral Implantology
JF - Journal of Oral Implantology
IS - 1
ER -