Violence and schizophrenia: Clozapine as a specific antiaggressive agent

Peter F Buckley, J. Bartell, K. Donenwirth, S. Lee, F. Torigoe, S. C. Schulz

Research output: Contribution to journalArticlepeer-review

127 Scopus citations


Pharmacological management of persistent aggression in patients with schizophrenia is a difficult clinical dilemma. Clozapine has been shown to be an effective agent in this regard. This study sought to compare the symptomatic response on the Brief Psychiatric Rating Scale (BPRS) between hostile schizophrenic patients and patients without aggression. While dramatic improvements were evident in aggression, both groups were indistinguishable with respect to BPRS response. These results suggest that clozapine may have a selective antiaggressive effect.

Original languageEnglish (US)
Pages (from-to)607-612
Number of pages6
JournalBulletin of the American Academy of Psychiatry and the Law
Issue number4
StatePublished - Dec 1 1995

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Law


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