Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

Hanspeter Pircher; Demetrius Moskophidis; Urs Rohrer; Kurt Bürki; Hans Hengartner; Rolf M. Zinkernagel

doi:10.1038/346629a0

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

Hanspeter Pircher, Demetrius Moskophidis, Urs Rohrer, Kurt Bürki, Hans Hengartner, Rolf M. Zinkernagel

Research output: Contribution to journal › Article › peer-review

509 Scopus citations

Abstract

Viruses persist in an immune population, as in the case of influenza, or in an individual, as postulated for human immunodeficiency virus, when they are able to escape existent neutralizing antibody responses by changing their antigens. It is now shown that viruses can in principle escape the immunosurveillance of virus-specific cytotoxic T cells by mutations that alter the relevant T-cell epitope.

Original language	English (US)
Pages (from-to)	629-633
Number of pages	5
Journal	Nature
Volume	346
Issue number	6285
DOIs	https://doi.org/10.1038/346629a0
State	Published - 1990
Externally published	Yes

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10.1038/346629a0

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title = "Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo",

abstract = "Viruses persist in an immune population, as in the case of influenza, or in an individual, as postulated for human immunodeficiency virus, when they are able to escape existent neutralizing antibody responses by changing their antigens. It is now shown that viruses can in principle escape the immunosurveillance of virus-specific cytotoxic T cells by mutations that alter the relevant T-cell epitope.",

author = "Hanspeter Pircher and Demetrius Moskophidis and Urs Rohrer and Kurt B{\"u}rki and Hans Hengartner and Zinkernagel, {Rolf M.}",

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T1 - Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

AU - Pircher, Hanspeter

AU - Moskophidis, Demetrius

AU - Rohrer, Urs

AU - Bürki, Kurt

AU - Hengartner, Hans

AU - Zinkernagel, Rolf M.

PY - 1990

Y1 - 1990

N2 - Viruses persist in an immune population, as in the case of influenza, or in an individual, as postulated for human immunodeficiency virus, when they are able to escape existent neutralizing antibody responses by changing their antigens. It is now shown that viruses can in principle escape the immunosurveillance of virus-specific cytotoxic T cells by mutations that alter the relevant T-cell epitope.

AB - Viruses persist in an immune population, as in the case of influenza, or in an individual, as postulated for human immunodeficiency virus, when they are able to escape existent neutralizing antibody responses by changing their antigens. It is now shown that viruses can in principle escape the immunosurveillance of virus-specific cytotoxic T cells by mutations that alter the relevant T-cell epitope.

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Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

Abstract

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