Vitamin D3 Inhibits Wnt/β-Catenin and mTOR Signaling Pathways in Human Uterine Fibroid Cells

Ayman Al-Hendy; Michael P Diamond; Sunil K Halder

doi:10.1210/jc.2015-3555

Vitamin D3 Inhibits Wnt/β-Catenin and mTOR Signaling Pathways in Human Uterine Fibroid Cells

Ayman Al-Hendy, Michael P Diamond, Sunil K Halder

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Vitamin D3 regulates Wnt/β-catenin and mTOR signaling pathways that are associated with cell proliferation and tumorigenicity, and thus vitamin D3 may have therapeutic utility as an effective, safe, long-term treatment option for human UFs.

Original language	English (US)
Pages (from-to)	1542-51
Number of pages	10
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	101
Issue number	4
DOIs	https://doi.org/10.1210/jc.2015-3555
State	Published - Apr 2016

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Journal Article

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10.1210/jc.2015-3555

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title = "Vitamin D3 Inhibits Wnt/β-Catenin and mTOR Signaling Pathways in Human Uterine Fibroid Cells",

abstract = "Vitamin D3 regulates Wnt/β-catenin and mTOR signaling pathways that are associated with cell proliferation and tumorigenicity, and thus vitamin D3 may have therapeutic utility as an effective, safe, long-term treatment option for human UFs.",

keywords = "Journal Article",

author = "Ayman Al-Hendy and Diamond, {Michael P} and Halder, {Sunil K}",

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AU - Al-Hendy, Ayman

AU - Diamond, Michael P

AU - Halder, Sunil K

PY - 2016/4

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N2 - Vitamin D3 regulates Wnt/β-catenin and mTOR signaling pathways that are associated with cell proliferation and tumorigenicity, and thus vitamin D3 may have therapeutic utility as an effective, safe, long-term treatment option for human UFs.

AB - Vitamin D3 regulates Wnt/β-catenin and mTOR signaling pathways that are associated with cell proliferation and tumorigenicity, and thus vitamin D3 may have therapeutic utility as an effective, safe, long-term treatment option for human UFs.

KW - Journal Article

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DO - 10.1210/jc.2015-3555

M3 - Article

C2 - 26820714

SN - 0021-972X

VL - 101

SP - 1542

EP - 1551

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 4

ER -

Vitamin D3 Inhibits Wnt/β-Catenin and mTOR Signaling Pathways in Human Uterine Fibroid Cells

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